Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Single-cell transcriptional atlas of the Chinese horseshoe bat (Rhinolophus sinicus) provides insight into the cellular mechanisms which enable bats to be viral reservoirs
Lili Ren,Chen Wu,Li Guo,Jiacheng Yao,Conghui Wang,Yan Xiao,Angela Oliveira Pisco,Zhihong Wu,Xiaobo Lei,Y.P. Liu,Shi L,Han L,Hui Zhang,Xiaoping Xiao,Zhong J,Hao Wu,Mengshuang Li,Mengshuang Li,Yanyi Huang,Jianbin Wang +19 more
TL;DR: A single-cell transcriptomic atlas of the Chinese horseshoe bat provides a molecular foundation for understanding the cell identities, functions and cellular receptor characteristics for viral reservoirs and zoonotic transmission.
Journal ArticleDOI
Managing the combined consequences of COVID-19 infection and lock-down policies on athletes: Narrative review and guidelines proposal for a safe return to sport
Jean-Bernard Fabre,Laurent Grélot,William Vanbiervielt,Julien Mazerie,Raphael Manca,Vincent Martin +5 more
TL;DR: Evaluation guidelines of fitness and health of athletes are proposed to reduce any lethal risk of practice, especially myocarditis and sudden cardiac death, and evaluate the combined consequences of the disease and detraining on the physical abilities and biological profile of athletes and monitor postinfection fatigue symptoms.
Journal ArticleDOI
Advances in Synthetic Biology and Biosafety Governance
TL;DR: In this article, the authors reviewed the recent progress made in the field of synthetic biology and combs laws and regulations in governing bio-risk issues and emphasized the urgent need for legislative and regulatory constraints and oversight to address the biological risks of synthetic biologists.
Journal ArticleDOI
Panduan aman “new normal” menghadapi pandemi covid-19
M. Nilzam Aly,Aprilia Nur'aini Rizma Outri,Ghina Rosyida,Aufa Hamidah,Annisa Septiana Ahmad,Hikmah Ayu Suryani,Afil Qurrota A’yuni,Putri Hamidah Khairunnisa,Nisrina Nadia Rachmadicha,Isrini Qaidatul Ilmi +9 more
TL;DR: The WEBINAR workshop as discussed by the authors was held online using the Zoom meeting platform and was held on June 18 th 2020 at 19.00 WIB with the speaker namely Ayu Tarantika Indreswari, S.Farm.
Journal ArticleDOI
When cancer encounters COVID-19 in China: what have we suffered, experienced and learned.
TL;DR: It is of significance to summarize the relevant experience of China in the prevention and control of COVID-19 infection and treatment of patients with cancer during the epidemic.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Journal ArticleDOI
SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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