Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis.
TL;DR: Olfactory and gustatory dysfunction are common symptoms in patients with COVID-19 and may represent early symptoms in the clinical course of infection and increased awareness of this fact may encourage earlier diagnosis and treatment, as well as heighten vigilance for viral transmission.
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People with Suspected COVID-19 Symptoms Were More Likely Depressed and Had Lower Health-Related Quality of Life: The Potential Benefit of Health Literacy.
Hoang C. Nguyen,Minh H. Nguyen,Binh N. Do,Cuong Q. Tran,Thao T.P. Nguyen,Khue M. Pham,Linh V. Pham,Khanh V. Tran,Trang T. Duong,Tien V. Tran,Thai H. Duong,Tham T. Nguyen,Quyen Nguyen,Thanh M. Hoang,Kien T. Nguyen,Thu T. M. Pham,Shwu-Huey Yang,Shwu-Huey Yang,Jane C.J. Chao,Jane C.J. Chao,Tuyen Van Duong +20 more
TL;DR: HL shows a protective effect on depression and HRQoL during the epidemic, and people with S-COVID-19-S had a higher depression likelihood and lower HRZoL than those without.
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Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong.
Vincent C.C. Cheng,Shuk-Ching Wong,Jonathan H. K. Chen,Cyril C. Y. Yip,Vivien W M Chuang,Owen Tak-Yin Tsang,Siddharth Sridhar,Jasper Fuk-Woo Chan,Pak-Leung Ho,Kwok-Yung Yuen +9 more
TL;DR: appropriate hospital infection control measures was able to prevent nosocomial transmission of SARS-CoV-2, and early airborne infection isolation, rapid molecular diagnostic testing, and contact tracing for healthcare workers with unprotected exposure in the hospitals was implemented.
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Epidemiology, virology, and clinical features of severe acute respiratory syndrome -coronavirus-2 (SARS-CoV-2; Coronavirus Disease-19).
TL;DR: The purpose of this review is to summarize known-to-date information about SARS-CoV-2, transmission of SARS, and clinical features, and to declare COVID-19 a pandemic on March 11, 2020.
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The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections.
Jatin Machhi,Jonathan Herskovitz,Ahmed M. Senan,Debashis Dutta,Barnali Nath,Maxim D. Oleynikov,Wilson R. Blomberg,Douglas D. Meigs,Mahmudul Hasan,Milankumar Patel,Peter Kline,Raymond Chuen-Chung Chang,Linda Chang,Howard E. Gendelman,Bhavesh D. Kevadiya,Bhavesh D. Kevadiya +15 more
TL;DR: Intense global efforts have targeted research into a better understanding of the epidemiology, molecular biology, pharmacology, and pathobiology of SARS-CoV-2 to provide the insights directed to curtailing this disease outbreak with intense international impact.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
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Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
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Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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