Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A systematic review and meta-analysis
Catherine R. Jutzeler,Lucie Bourguignon,Caroline Weis,Bobo Tong,Cyrus Wong,Bastian Rieck,Hans Pargger,Sarah Tschudin-Sutter,Adrian Egli,Karsten M. Borgwardt,Matthias Walter +10 more
TL;DR: The meta-analyses revealed important risk factors that are associated with severity and mortality of COVID-19 and revealed heterogeneity between studies varied substantially.
Journal ArticleDOI
Evolutionary analysis and lineage designation of SARS-CoV-2 genomes.
Xiaolu Tang,Ruochen Ying,Xinmin Yao,Guanghao Li,Guanghao Li,Changcheng Wu,Yiyuli Tang,Zhida Li,Bishan Kuang,Feng Wu,Changsheng Chi,Xiaoman Du,Yi Qin,Shenghan Gao,Songnian Hu,Juncai Ma,Tiangang Liu,Xinghuo Pang,Jianwei Wang,Guoping Zhao,Wenjie Tan,Ya-Ping Zhang,Xuemei Lu,Jian Lu +23 more
TL;DR: Wang et al. as discussed by the authors analyzed single nucleotide variants (SNVs) in 121,618 high-quality SARS-CoV-2 genomes and divided these viral genomes into two major lineages (L and S) based on variants at sites 8782 and 28144.
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Exploring sodium glucose co-transporter-2 (SGLT2) inhibitors for organ protection in COVID-19
Beatriz Fernandez-Fernandez,Luis D'Marco,José Luis Górriz,Conxita Jacobs-Cachá,Mehmet Kanbay,Sergio Luis-Lima,Sergio Luis-Lima,Esteban Porrini,Esteban Porrini,Esteban Porrini,Pantelis Sarafidis,María José Soler,María José Soler,Alberto Ortiz +13 more
TL;DR: The potential benefits and risks of SGLT2 inhibitors in COVID-19 and an ongoing clinical trial testing the impact of dapagliflozin on outcomes in patients with respiratory failure are discussed.
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Awareness and perception of COVID-19 among the general population: A Middle Eastern survey.
TL;DR: In this paper, a cross-sectional survey was conducted between the 19th and 22nd of March to assess the public's awareness toward COVID-19 and found that more than half of the Jordanian (56.8%) and Iraqi participants (53.2%) showed average or adequate awareness.
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Targeting pivotal inflammatory pathways in COVID-19: A mechanistic review.
TL;DR: In the present study, precise inflammatory pathways triggered by SARS-CoV-2, along with potential therapeutic candidates have been discussed, and inflammation seems to play a more critical role toward COVID-19 complications.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Journal ArticleDOI
SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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