Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Characterization of cells susceptible to SARS-COV-2 and methods for detection of neutralizing antibody by focus forming assay
E. Taylor Stone,Elizabeth Geerling,Tara L. Steffen,Mariah Hassert,Alexandria Dickson,Jacqueline F. Spencer,Karoly Toth,Richard J. DiPaolo,James D. Brien,Amelia K. Pinto +9 more
TL;DR: The lab has adapted focus forming assays for SARS-CoV-2 using Vero CCL-81 cells using the focus forming assay as the basis for screening cell susceptibility and to develop a focus reduction neutralization test.
Journal ArticleDOI
COVID-19 and SARS-CoV-2: Everything we know so far - A comprehensive review
TL;DR: In this article, Naz et al. provide a comprehensive summary of the major aspects and important scientific findings so far, about COVID-19 and SARS-CoV-2 in a single article for ready reference.
Journal Article
Clinical features and management of COVID-19: A systematic review
TL;DR: This study shows the multisystem involvement of COVID-19 with dominant respiratory features followed by the musculoskeletal, gastrointestinal system and others, and major modalities of management included supportive, antiviral and antibiotic therapy.
Journal ArticleDOI
Melatonin to Reduce Death Toll Due to COVID-19: From Innate to Adaptive Immune Response
TL;DR: A new, nonspecific medication, which could be used both as a preventive and a curative measure to slow down the progression of Coronavirus disease 2019 (COVID-19) until a more specific treatment is available is highlighted.
Journal ArticleDOI
In-Silico Pangenomics of SARS-CoV-2 Isolates Reveal Evidence for Subtle Adaptive Expression Strategies, Continued Clonal Evolution, and Sub-Clonal Emergences, Despite Genome Stability
Kamaleldin B. Said,Ahmed Alsolami,Anas Fathuldeen,Fawwaz Alshammari,Walid Alhiraabi,Salem Alaamer,Hamad Alrmaly,Fahad Aldamadi,Dakheel F. Aldakheel,Safia Moussa,Ahmed Al Jadani,Abdulhafiz Bashir +11 more
TL;DR: In this paper, high sequence identity and phylogenetic tree concordance were obtained with isolates from different regions, and the abundance of transversions, slippery sequences, and ON/OFF molecular structures, implying adaptive expressions had occurred, despite clonal evolution and genome stability.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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