Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Can symptoms of anosmia and dysgeusia be diagnostic for COVID-19?
TL;DR: This work aimed to investigate the diagnostic value of symptoms of anosmia and dysgeusia for COVID‐19, a potential neurological manifestation of coronavirus‐2019.
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Label-free detection of SARS-CoV-2 Spike S1 antigen triggered by electroactive gold nanoparticles on antibody coated fluorine-doped tin oxide (FTO) electrode.
TL;DR: In this article, the authors reported fabricated fluorine doped tin oxide (FTO) electrodes/gold nanoparticles (AuNPs) complex coupled with in-house developed SARS-CoV-2 spike S1 antibody (SARS CoV-1 Ab) to measure the response with Cyclic Voltammetry (CV) and Differential Pulse Voltamermetry (DPV).
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The potential impact of the COVID-19 pandemic on global antimicrobial and biocide resistance: an AMR Insights global perspective
Shamshul Ansari,J. P. Hays,A. Kemp,Raymond C. Okechukwu,Jayaseelan Murugaiyan,Mutshiene Deogratias Ekwanzala,Mutshiene Deogratias Ekwanzala,M. J. Ruiz Alvarez,M. Paul-Satyaseela,Chidozie Declan Iwu,Clara Ballesté-Delpierre,E. Septimus,L. Mugisha,J. Fadare,S. Chaudhuri,V. Chibabhai,Wadanamby, Jmrww, Daoud, Z.,Y. Xiao,T. Parkunan,Y. Khalaf,N. M. M'Ikanatha,M. B. M. van Dongen +21 more
TL;DR: In this article, the authors present a brief overview of the COVID-19 pandemic and associated issues that could influence the pandemic's effect on global AMR, including increased biocide use, antimicrobial stewardship/infection control, AMR awareness, the need for diagnostics, and the usefulness of vaccination.
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Knowledge, attitudes, and practices of Sudanese residents towards COVID-19.
TL;DR: It was found that women and people aged 18-25 years were more knowledgeable and had more positive attitudes towards COVID-19, and it is hoped that concerned authorities will establish awareness programmes to improve the ability to combat this disease.
Journal ArticleDOI
Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics Simulations.
Rafat Zrieq,Iqrar Ahmad,Mejdi Snoussi,Emira Noumi,Marcello Iriti,Fahad D. Algahtani,Harun M. Patel,Mohd Saeed,Munazzah Tasleem,Shadi Sulaiman,Kaïss Aouadi,Kaïss Aouadi,Adel Kadri,Adel Kadri +13 more
TL;DR: In this paper, tomatidine and patchouli alcohol have been selected as potential drugs for combating the SARS-CoV-2 infection and molecular docking analyses revealed that both drugs can bind the active site of 3CLpro, PLpro, NSP15, COX-2 and PLA2 targets with a number of important binding interactions.
References
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Journal ArticleDOI
Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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