Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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COVID-19 pandemic: the implications of the natural history, challenges of diagnosis and management for care in sub-Saharan Africa
L O Omo-Aghoja,E.G. Moke,K.K. Anachuna,A.I. Omogbiya,E.K. Umukoro,Pere-Ebi Yabrade Toloyai,Tarela Melish Elias Daubry,Anthony T. Eduviere +7 more
TL;DR: Responses by most nations of SSA were adhoc, paucity of public health awareness strategies and absence of legislations that would help enforce preventive measures, as well as limited facilities and institutional capacities to deliver needed interventions.
Book ChapterDOI
COVID-19 Pandemic: Animal Cross Talk and Comparison Between nSARS-CoV-2 and Animal Coronaviruses
TL;DR: In this paper, the authors discuss the predicted roles of animals in the COVID-19 pandemic, along with comparisons of nSARS-CoV-2 with other animal CoVs.
Journal ArticleDOI
The Differences and Changes of Semi-Quantitative and Quantitative CT Features of Coronavirus Disease 2019 Pneumonia in Patients With or Without Smoking History.
TL;DR: In this paper, the authors assess CT features of COVID-19 patients with different smoking status using quantitative and semi-quantitative technologies and investigate changes of CT features in different disease states between the two groups.
Journal ArticleDOI
Repurposing Antiviral Drugs to Inhibit SARS-CoV-2 Papin-Like Protease Activity
Ibrahim Khater,Aaya Nassar +1 more
TL;DR: This study aims to examine known direct acting antivirals (DAA) against SARS-CoV-2 papin like protease solved structure to examine the free natural affinity of the binding ligand to catalytic residues and substrate binding pockets without forcing the docking of ligands to active site.
Journal ArticleDOI
Epidemiology and Treatment Options for COVID-19: A Review
Babatunde O. Adetuyi,Peace A. Olajide,E.H. Awoyelu,Oluwatosin A. Adetuyi,Oluwaseun A. Adebisi,Julius Kola Oloke +5 more
TL;DR: Genomic analysis revealed that SARS-CoV-2 is phylogenetically related to severe acute respiratory syndrome-like (SARS-like) bat viruses; therefore, bats could be the possible primary reservoir.
References
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Journal ArticleDOI
Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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