Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Longitudinal Monitoring of SARS-CoV-2 IgM and IgG Seropositivity to Detect COVID-19.
Raymond T. Suhandynata,Melissa A Hoffman,Michael J. Kelner,Ronald W. McLawhon,Sharon L. Reed,Robert L. Fitzgerald +5 more
TL;DR: Suhandynata et al. as mentioned in this paper evaluated the analytical performance parameters of the Diazyme SARS-CoV-2 IgM/IgG serology assays and described the kinetics of IgM and IgG seroconversion observed in patients with PCR-confirmed COVID-19 who were admitted to our hospital.
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The Potential Intermediate Hosts for SARS-CoV-2
Jie Zhao,Wei Cui,Bao-ping Tian +2 more
TL;DR: The results demonstrate the critical role of the intermediate host in the transmission chain of SARS-CoV-2, and the efficient intervention on this basis may be useful to prevent further deterioration of COVID-19.
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Prevalence and Mortality of COVID-19 Patients With Gastrointestinal Symptoms: A Systematic Review and Meta-analysis.
Raseen Tariq,Raseen Tariq,Srishti Saha,Fateeha Furqan,Leslie C. Hassett,Darrell S. Pardi,Sahil Khanna +6 more
TL;DR: A systematic review and meta-analysis evaluating the prevalence of gastrointestinal (GI) symptoms and mortality in patients diagnosed with coronavirus disease 2019 (COVID-19) found that infection and reporting GI symptoms were similar to overall mortality.
Journal ArticleDOI
The Pathogenesis of Coronavirus Disease 2019 (COVID-19): Evaluation and Prevention.
Hayat Ouassou,Loubna Kharchoufa,Mohamed Bouhrim,Nour Elhouda Daoudi,Hamada Imtara,Noureddine Bencheikh,Amine Elbouzidi,Mohamed Bnouham +7 more
TL;DR: The epidemiology, transmission, symptoms, and treatment of this disease, as well as future strategies to manage the spread of this fatal coronavirus, are highlighted.
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The architecture of the SARS-CoV-2 RNA genome inside virion.
Changchang Cao,Zhaokui Cai,Xia Xiao,Jian Rao,Juan Chen,Naijing Hu,Minnan Yang,Xiaorui Xing,Yongle Wang,Manman Li,Bing Zhou,Xiangxi Wang,Jianwei Wang,Yuanchao Xue +13 more
TL;DR: This work reconstructed the tertiary structure of the SARS-CoV-2 genome and revealed a surprisingly "unentangled globule" conformation, and provides a framework for studying the genome structure, function, and dynamics of emerging deadly RNA viruses.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
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Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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