Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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ZWA: Viral genome assembly and characterization hindrances from virus-host chimeric reads; a refining approach.
Nikolas Dovrolis,Katerina Kassela,Konstantinos T. Konstantinidis,Adamantia Kouvela,Stavroula Veletza,Ioannis Karakasiliotis +5 more
TL;DR: The Zero Waste Algorithm (ZWA) as mentioned in this paper performs context-depended trimming of chimeric reads, precisely removing their ribosomal RNA (rRNA) moiety.
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Sanger Sequencing for Molecular Diagnosis of SARS-CoV-2 Omicron Subvariants and Its Challenges
TL;DR: In this article , the authors used Sanger sequencing to diagnose Omicron subvariants when the samples harbor a high level of coexisting minor subvariant sequences with multi-allelic single nucleotide polymorphisms (SNPs) or possible recombinant OmicRON subvants containing a BA.4/BA.5 with L84I mutation in the S gene NTD.
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Seasonal correlation of meteorological parameters and PM2.5 with the COVID-19 confirmed cases and deaths in Baghdad, Iraq
Bassim Mohammed Hashim,Saadi K. Al-Naseri,Alaa Hamadi,Bijay Halder,Shamsuddin Shahid,Zaher Mundher Yaseen +5 more
TL;DR: In this article , the seasonal association of weekly averages of meteorological parameters, such as wind speed, solar radiation, temperature, relative humidity, and air pollutant PM2.5, with confirmed COVID-19 cases and deaths in Baghdad, Iraq, a major megacity of the Middle East, for the period June 2020 to August 2021.
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Prediction of Re-positivity for Coronavirus Nucleic Acid Among COVID-19 Patients in the Recovery Phase
Shu-fen Zhu,Bo Sun,Jin-kuang Li,Yue Cai,Peng-fei Li,Ji-chang Hong,Jin-hai Li,Shi-wen Xu,Xiao-yang Li,Chen-wei Xue,Bin-bin Gu,Jian-fen Wu,Xian-Bin Zhou,Hong Suo,Pei-lin Duan,Xin-xin Wu,Shao-wei Li +16 more
TL;DR: Wang et al. as discussed by the authors evaluated the risk predictors associated with re-positivity for virus nucleic acid and developed a risk prediction model for the repositivity of virus nucleIC acid.
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Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model
TL;DR: In this paper , an in vitro cellular model was developed to explore the regulation of ACE2 expression and its correlation with ACE2-mediated viral entry, which can be used for the screening of novel therapeutic candidates that may be warranted for further preclinical and clinical studies on COVID-19 countermeasures.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Journal ArticleDOI
SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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