Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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Severe acute respiratory syndrome coronavirus 2 for physicians: Molecular characteristics and host immunity (Review).
TL;DR: Wang et al. as discussed by the authors have shown that increased ACE2 expression may upregulate the viral load indirectly by increasing the baseline level of infectious virus particles, which may explain why this type of CoV triggers severe inflammatory responses and immune damage and its associated complications.
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Early versus late intubation in COVID-19 patients failing helmet CPAP: A quantitative computed tomography study
Lorenzo Ball,Chiara Robba,Jacob Herrmann,Sarah E. Gerard,Yi Xin,Maria Pigati,Andrea Berardino,Francesca Iannuzzi,Denise Battaglini,Iole Brunetti,G. Minetti,Sara Seitun,Antonio Vena,Daniele Roberto Giacobbe,Matteo Bassetti,Patricia R. M. Rocco,Maurizio Cereda,Lucio Castellan,Nicolò Patroniti,Paolo Pelosi +19 more
TL;DR: In this article , the effects of timing of intubation in COVID-19 patients that fail to tolerate continuous positive airway pressure (h-CPAP) on progression and severity of disease were described.
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Socio-Economic Implications of the Coronavirus Pandemic: Early Review and Projections, Nigeria in Focus
TL;DR: Covid19 presents with non-specific clinical manifestations caused by SARS-CoV-2, a new variant of virus called coronaviru sout break started from Wuhan, Hubei Province of China as an epidemic in late December, 2019.
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Antiviral Efficacy of Medicinal Plants Against Respiratory Viruses: Respiratory Syncytial Virus (RSV) and Coronavirus (COV) / COVID 19
TL;DR: This review attempts to address the importance of herbs for the treatment of respiratory virus because rapid spread of the infection and preventing the use of allotropic medicine.
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Risk of coronavirus disease 2019 (COVID-19) infection on leukemia patients: basic science to clinical aspect
TL;DR: A review article aims to explain the molecular mechanism, including leukemia patients' immune system with COVID-19 and recommendations for patients and hemato-oncologists.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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