Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Lili Ren,Ye Ming Wang,Zhiqiang Wu,Zi Chun Xiang,Li Guo,Teng Xu,Yong Zhong Jiang,Yan Xiong,Li Yongjun,Xing Wang Li,Hui Li,Guo Hui Fan,Guo Hui Fan,Xiao Ying Gu,Xiao Ying Gu,Yan Xiao,Hong Gao,Jiu Yang Xu,Fan Yang,Xinming Wang,Chao Wu,Lan Chen,Yi Wei Liu,Bo Liu,Jian Yang,Xiao Rui Wang,Jie Dong,Li Li,Chao Lin Huang,Jian Ping Zhao,Yi Hu,Zhen Shun Cheng,Lin Lin Liu,Zhao Hui Qian,Chuan Qin,Qi Jin,Bin Cao,Bin Cao,Jianwei Wang +38 more
TLDR
A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans and the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.Citations
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COVID-19: a novel zoonotic disease caused by a coronavirus from China: what we know and what we don't.
John S. Mackenzie,David W. Smith +1 more
TL;DR: The evolution of the outbreak, and the known properties of the novel virus, SARS-CoV-2 and the clinical disease it causes, COVID-19 are described and some of the important gaps in knowledge of the virus and the disease it cause are commented on.
Journal ArticleDOI
COVID-19: Disease, management, treatment, and social impact.
TL;DR: It was analyzed that a combination of antiviral drugs with hydroxyl-chloroquine and azithromycin (with the consultation of a medical practitioner) may be the best option to treat the patients, depending on the patient's conditions and symptoms, and Unani therapy may be useful along with allopathic treatment.
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COVID-19 in Africa: care and protection for frontline healthcare workers.
Matthew Chersich,Glenda Gray,Lee Fairlie,Quentin Eichbaum,Quentin Eichbaum,Susannah H. Mayhew,Brian W. Allwood,Rene English,Fiona Scorgie,Stanley Luchters,Greg Simpson,Marjan Mosalman Haghighi,Minh D. Pham,Minh D. Pham,Helen Rees +14 more
TL;DR: There are multiple ways that international support and national commitment could help safeguard healthcare workers in Africa, essential for limiting the pandemic’s potentially devastating heath, socio-economic and security impacts on the continent.
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The Origins of SARS-CoV-2: A Critical Review
Edward C. Holmes,Stephen A. Goldstein,Angela L. Rasmussen,David Robertson,Alexander Crits-Christoph,Joel O. Wertheim,Simon J. Anthony,Wendy S. Barclay,Maciej F. Boni,Peter C. Doherty,Jeremy Farrar,Jemma L. Geoghegan,Xiaowei Jiang,Julian L. Leibowitz,Stuart J. D. Neil,Tim Skern,Susan R. Weiss,Michael Worobey,Kristian G. Andersen,Robert F. Garry,Andrew Rambaut +20 more
TL;DR: In this article, a review of the current scientific evidence that may help clarify the origin of SARS-CoV-2 is presented, with a focus on how severe acute respiratory syndrome coronavirus 2 emerged in the human population.
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The transmission and diagnosis of 2019 novel coronavirus infection disease (COVID-19): A Chinese perspective.
Yu Han,Hailan Yang +1 more
TL;DR: This research presents selected available cases of COVID‐19 in China to better understand the transmission and diagnosis regarding this infectious disease.
References
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Journal ArticleDOI
SARS and MERS: recent insights into emerging coronaviruses
TL;DR: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronav virus into the human population in the twenty-first century, and the current state of development of measures to combat emerging coronaviruses is discussed.
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