Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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COVID-19 in Immunosuppressed Children
Emanuele Nicastro,Lucio Verdoni,Laura Rachele Bettini,Giovanna Zuin,Adriana Balduzzi,Giovanni Montini,Andrea Biondi,Lorenzo D'Antiga +7 more
TL;DR: In this article, a competent recognition by the innate immune system and controlled pro-inflammatory signaling seem to be the pillars of an effective response and the premise for pathogen clearance in SARS-CoV-2 infection.
Posted ContentDOI
Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication
Jennifer S. Chen,Mia Madel Alfajaro,Jin Wei,Ryan D. Chow,Renata B. Filler,Stephanie C. Eisenbarth,Craig B. Wilen +6 more
TL;DR: The purpose of this study was to dissect the effect of NSAIDs on COVID-19 in terms of SARS-CoV-2 entry and replication, and suggest that COX-2 signaling may instead play a role in regulating the lung inflammation and injury observed in CO VID-19 patients.
Journal ArticleDOI
Virtual Drug Repurposing Study Against SARS-CoV-2 TMPRSS2 Target
TL;DR: A hybrid combined molecular modeling approach in virtual drug screening repurposing study to identify new compounds against SARS-CoV-2 target benzquercin can be considered to be used as inhibitor of TMPRSS2 at the clinical studies.
Journal ArticleDOI
The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis
Abbas F. Almulla,Thitiporn Supasitthumrong,Chavit Tunvirachaisakul,A. A. Abo Algon,Hussein Kadhem Al-Hakeim,Michael Maes +5 more
TL;DR: In this article , a systematic review and meta-analysis of the TRYCAT pathway, including the levels of TRP and kynurenine (KYN) and the activity of IDO, as measured by the ratio of KYN/TRP.
Journal ArticleDOI
Global characterization of B cell receptor repertoire in COVID-19 patients by single-cell V(D)J sequencing.
Xiyun Jin,Wenyang Zhou,Meng Luo,Pingping Wang,Zhaochun Xu,Kexin Ma,Huimin Cao,Chang Xu,Yan Huang,Rui Cheng,Lixing Xiao,Xiaoyu Lin,Fenglan Pang,Yiqun Li,Huan Nie,Qinghua Jiang +15 more
TL;DR: In this paper, the authors used the single-cell V(D)J sequencing to characterize the BCR repertoire across convalescent COVID-19 patients, and they found that the diversity of BCR diversity was significantly reduced in disease compared with healthy controls.
References
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
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Fast gapped-read alignment with Bowtie 2
TL;DR: Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
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ggplot2: Elegant Graphics for Data Analysis
TL;DR: This book describes ggplot2, a new data visualization package for R that uses the insights from Leland Wilkisons Grammar of Graphics to create a powerful and flexible system for creating data graphics.
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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