Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Journal ArticleDOI
Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples.
Brendan Miller,Ana Silverstein,Melanie Flores,Kevin Cao,Hiroshi Kumagai,Hiroshi Kumagai,Hemal H. Mehta,Kelvin Yen,Su-Jeong Kim,Pinchas Cohen +9 more
TL;DR: In this article, the effect of SARS-CoV-2 on the mtDNA-encoded gene expression and Mitochondrial Antiviral Signaling (MAVS) protein signaling was investigated.
Journal ArticleDOI
Human nasal and lung tissues infected ex vivo with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tract.
Or Alfi,Arkadi Yakirevitch,Arkadi Yakirevitch,Ori Wald,Ori Wandel,Uzi Izhar,Esther Oiknine-Djian,Yuval Nevo,Sharona Elgavish,Elad Dagan,Elad Dagan,Ory Madgar,Ory Madgar,Gilad Feinmesser,Gilad Feinmesser,Eli Pikarsky,Michal Bronstein,Olesya Vorontsov,Wayne B. Jonas,John A. Ives,Joan A.G. Walter,Zichria Zakay-Rones,Menachem Oberbaum,Amos Panet,Dana G. Wolf +24 more
TL;DR: In this paper, the early stages of SARS-CoV-2 infection at the mucosal entry site have remained unexplored, while the imbalanced innate immune response of end stage coronavirus disease 2019 (COVID-19) has been extensively studied.
Journal ArticleDOI
Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19
Madalina E. Carter-Timofte,Madalina E. Carter-Timofte,Sofie E. Jørgensen,Sofie E. Jørgensen,Mette Ratzer Freytag,Mette Ratzer Freytag,Michelle M. Thomsen,Michelle M. Thomsen,Nanna-Sophie Brinck Andersen,Nanna-Sophie Brinck Andersen,Ali Al-Mousawi,Ali Al-Mousawi,Alon Schneider Hait,Alon Schneider Hait,Trine H. Mogensen,Trine H. Mogensen +15 more
TL;DR: A potential genetic effect on host immune response pathways leading to increased susceptibility to SARS-CoV-2 infection is reasoned and candidate immune pathways that may be compromised in otherwise healthy individuals with fulminating COVID-19 are suggested.
Journal ArticleDOI
Pathogenetic profiling of COVID-19 and SARS-like viruses.
Zulkar Nain,Humayan Kabir Rana,Pietro Liò,Sheikh Mohammed Shariful Islam,Matthew A. Summers,Mohammad Ali Moni +5 more
TL;DR: Protein–chemical interactions suggest cyclosporine, resveratrol and quercetin as promising drug candidates against COVID-19 as well as other SARS-like viral infections.
Journal ArticleDOI
The efficacy of IL-6 inhibitor Tocilizumab in reducing severe COVID-19 mortality: a systematic review
Avi Gurion Kaye,Robert Siegel +1 more
TL;DR: Positive evidence is provided for the potential efficacy of TCZ to treat severe COVID-19, validating the ethical basis and merit of ongoing randomized controlled clinical trials.
References
More filters
Journal ArticleDOI
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
Journal ArticleDOI
Fast gapped-read alignment with Bowtie 2
TL;DR: Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
Book
ggplot2: Elegant Graphics for Data Analysis
TL;DR: This book describes ggplot2, a new data visualization package for R that uses the insights from Leland Wilkisons Grammar of Graphics to create a powerful and flexible system for creating data graphics.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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