Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Journal ArticleDOI
Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection.
Martina Severa,Roberta Antonina Diotti,Marilena P. Etna,Fabiana Rizzo,Stefano Fiore,Daniela Ricci,Marco Iannetta,Alessandro Sinigaglia,Alessandra Lodi,Nicasio Mancini,Elena Criscuolo,Massimo Clementi,Massimo Andreoni,Stefano Balducci,Luisa Barzon,Paola Stefanelli,Nicola Clementi,Eliana M. Coccia +17 more
TL;DR: In this paper, the early interaction between SARS-CoV-2 and immune cells was investigated by interrogating an in vitro human peripheral blood mononuclear cell (PBMC)-based experimental model.
Posted ContentDOI
SRSF protein kinases 1 and 2 are essential host factors for human coronaviruses including SARS-CoV-2
Tomer M Yaron,Brook E. Heaton,Tyler Levy,Jared L. Johnson,Tristan X Jordan,Benjamin M. Cohen,Alexander Kerelsky,Ting-Yu Lin,Katarina M. Liberatore,Danielle K. Bulaon,Edward R. Kastenhuber,Marisa N. Mercadante,Kripa Shobana-Ganesh,Long He,Robert E. Schwartz,Shuibing Chen,Harel Weinstein,Oliver Elemento,Elena Piskounova,Benjamin E. Nilsson-Payant,Gina Lee,Joseph D. Trimarco,Kaitlyn N. Burke,Cait E. Hamele,Ryan R. Chaparian,Alfred T. Harding,Aleksandra Tata,Xinyu Zhu,Purushothama Rao Tata,Clare M. Smith,Anthony Possemato,Sasha Tkachev,Peter Hornbeck,Sean A. Beausoleil,Shankara Anand,François Aguet,Gad Getz,Andrew D. Davidson,Kate J. Heesom,Maia Kavanagh-Williamson,David A. Matthews,Benjamin R. tenOever,Lewis C. Cantley,John Blenis,Nicholas S. Heaton +44 more
TL;DR: A genome-wide screen in human lung epithelial cells is performed to identify potential host therapeutic targets and suggests that SRPK1/2-targeted therapies may be an efficacious strategy to prevent or treat COVID-19 and other coronavirus-mediated diseases.
Journal ArticleDOI
PD-L1 Dysregulation in COVID-19 Patients.
Francesco Sabbatino,Valeria Conti,Gianluigi Franci,Carmine Sellitto,Valentina Manzo,Pasquale Pagliano,Emanuela De Bellis,Alfonso Masullo,Francesco Antonio Salzano,Alessandro Caputo,Ilaria Peluso,Pio Zeppa,Giosuè Scognamiglio,Giuseppe Greco,Carla Zannella,Michele Ciccarelli,Claudia Cicala,Carmine Vecchione,Amelia Filippelli,Stefano Pepe +19 more
TL;DR: Wang et al. as mentioned in this paper showed that PD-L1 upregulation is induced by SARS-CoV-2 in infected epithelial cells and is dysregulated in several types of immune cells of COVID-19 patients including monocytes, neutrophils, gamma delta T cells and CD4+ T cells.
Posted ContentDOI
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro.
Tomer M. Yaron,Brook E. Heaton,Tyler Levy,Jared L. Johnson,Tristan X. Jordan,Benjamin M. Cohen,Alexander Kerelsky,Ting-Yu Lin,Katarina M. Liberatore,Danielle K. Bulaon,Edward R. Kastenhuber,Marisa N. Mercadante,Kripa Shobana-Ganesh,Long He,Robert E. Schwartz,Shuibing Chen,Harel Weinstein,Olivier Elemento,Elena Piskounova,Benjamin E. Nilsson-Payant,Gina Lee,Joseph D. Trimarco,Kaitlyn N. Burke,Cait E. Hamele,Ryan R. Chaparian,Alfred T. Harding,Aleksandra Tata,Xinyu Zhu,Purushothama Rao Tata,Clare M. Smith,Anthony Possemato,Sasha Tkachev,Peter Hornbeck,Sean A. Beausoleil,Shankara Anand,François Aguet,Gad Getz,Gad Getz,Andrew D. Davidson,Kate J. Heesom,Maia Kavanagh-Williamson,David A. Matthews,Benjamin R. tenOever,Lewis C. Cantley,John Blenis,Nicholas S. Heaton +45 more
TL;DR: The data suggest that repurposing or developing novel host-kinase directed therapies may be an efficacious strategy to prevent or treat COVID-19 and other coronavirus-mediated diseases.
Journal ArticleDOI
Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: prospective cohort study.
Dongli Song,Dongli Song,Mary Prahl,Stephanie L. Gaw,Sudha Rani Narasimhan,Sudha Rani Narasimhan,Daljeet S Rai,Angela Huang,Claudia V Flores,Christine Y. Lin,Unurzul Jigmeddagva,Alan H.B. Wu,Lakshmi Warrier,Justine Levan,Catherine B T Nguyen,Perri Callaway,Lila A. Farrington,Gonzalo R Acevedo,Veronica J. Gonzalez,Anna Vaaben,Phuong Nguyen,Elda Atmosfera,Constance Marleau,Christina Anderson,Christina Anderson,Sonya Misra,Sonya Misra,Monica Stemmle,Monica Stemmle,Maria Cortes,Jennifer McAuley,Nicole Metz,Rupalee Patel,Matthew Nudelman,Susan Abraham,Susan Abraham,James A. Byrne,James A. Byrne,Priya Jegatheesan,Priya Jegatheesan +39 more
TL;DR: In this article, a prospective observational study was conducted to investigate maternal immunoglobulins' response to SARS-CoV-2 infection during pregnancy and IgG transplacental transfer, to characterise neonatal antibody response, and to follow actively and passively acquired antibodies in infants.
References
More filters
Journal ArticleDOI
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
Journal ArticleDOI
Fast gapped-read alignment with Bowtie 2
TL;DR: Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
Book
ggplot2: Elegant Graphics for Data Analysis
TL;DR: This book describes ggplot2, a new data visualization package for R that uses the insights from Leland Wilkisons Grammar of Graphics to create a powerful and flexible system for creating data graphics.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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