Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
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Why COVID-19 is less frequent and severe in children: a narrative review
TL;DR: Property of the immune system including a less vigorous adaptive system beside a preliminary potent innate response and a trained immunity alongside a healthier respiratory system, and their interactions, might protect children against SARS-CoV-2 infection.
Functional Landscape of SARS-CoV-2 Cellular Restriction (preprint)
Martin-Sancho, Laura, Lewinski, Mary K.,Pache, Lars, Stoneham, Charlotte A.,Yin, Xin, Pratt, Dexter, Churas, Christopher P.,Anshu P. Gounder,Nguyen, Courtney, Pu, Yuan, Oom, Aaron L.,Miorin, Lisa, Rodriguez-Frandsen, Ariel, Urbanowski, Matthew, Shaw, Megan L.,Max W. Chang,Benner, Christopher, Frieman, Matthew B.,Garcia-Sastre, Adolfo, Ideker, Trey, Hultquist, Judd F.,Guatelli, John, Chanda, Summit K. +9 more
TL;DR: A large-scale gain-of-function analysis evaluated the impact of human interferon stimulated genes (ISGs) on viral replication and defined the molecular basis of early innate immune control of viral infection.
Journal ArticleDOI
Interrelationship Between Coronavirus Infection and Liver Disease
TL;DR: Although the primary clinical manifestation is pulmonary disease, increasing data support the involvement of multiple organ systems, including the gastrointestinal tract and liver, with more than 60% of patients presenting with GI symptoms and a significant proportion presenting with elevated liver biochemistries.
Journal ArticleDOI
Recent insights for the emerging COVID-19: drug discovery, therapeutic options and vaccine development.
TL;DR: The present review will give exhaustive details of extensive researches concerning the drug discovery and therapeutic options for CO VID-19 as well as some insightful discussions of the status of COVID-19.
Journal ArticleDOI
AhR and IDO1 in pathogenesis of Covid-19 and the "Systemic AhR Activation Syndrome:" a translational review and therapeutic perspectives.
Waldemar A. Turski,Artur Wnorowski,Gabrielle N. Turski,Gabrielle N. Turski,Christopher A. Turski,Christopher A. Turski,Lechoslaw Turski +6 more
TL;DR: It is hypothesize that elimination of factors known to up-regulate AhRs, or implementation of measures known to down- Regulate AhR, should decrease severity of infection.
References
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TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
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Fast gapped-read alignment with Bowtie 2
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ggplot2: Elegant Graphics for Data Analysis
TL;DR: This book describes ggplot2, a new data visualization package for R that uses the insights from Leland Wilkisons Grammar of Graphics to create a powerful and flexible system for creating data graphics.
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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