Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Immunological considerations for COVID-19 vaccine strategies.
Mangalakumari Jeyanathan,Sam Afkhami,Fiona Smaill,Matthew S. Miller,Brian D. Lichty,Zhou Xing +5 more
TL;DR: The immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies are discussed and their strengths and potential shortfalls are examined, and inferences about their chances of success are made.
Journal ArticleDOI
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
Rajendra Karki,Bhesh Raj Sharma,Shraddha Tuladhar,Evan P. Williams,Lillian Zalduondo,Parimal Samir,Min Zheng,Balamurugan Sundaram,Balaji Banoth,R. K. Subbarao Malireddi,Patrick Schreiner,Geoffrey Neale,Peter Vogel,Richard Webby,Colleen B. Jonsson,Thirumala-Devi Kanneganti +15 more
TL;DR: It is suggested that blocking the cytokine-mediated inflammatory cell death signaling pathway identified here may benefit patients with COVID-19 or other infectious and autoinflammatory diseases by limiting tissue damage/inflammation.
Journal ArticleDOI
A dynamic COVID-19 immune signature includes associations with poor prognosis.
Adam Laing,Anna Lorenc,Irene del Molino del Barrio,Irene del Molino del Barrio,Abhishek Das,Abhishek Das,Matthew Fish,Matthew Fish,Leticia Monin,Miguel Muñoz-Ruiz,Duncan R. McKenzie,Thomas Hayday,Isaac Francos-Quijorna,Shraddha Kamdar,Magdalene Joseph,Daniel Davies,Daniel Davies,Richard Davis,Aislinn Jennings,Aislinn Jennings,Iva Zlatareva,Pierre Vantourout,Yin Wu,Yin Wu,Yin Wu,Vasiliki Sofra,Florencia Cano,Maria Greco,Efstathios Theodoridis,Joshua D. Freedman,Sarah Gee,Julie Nuo En Chan,Sarah Ryan,Eva Bugallo-Blanco,Pärt Peterson,Kai Kisand,Liis Haljasmägi,Loubna Chadli,Philippe Moingeon,Lauren Martinez,Blair Merrick,Karen Bisnauthsing,Kate Brooks,Mohammad A. A. Ibrahim,Jeremy Mason,Federico Lopez Gomez,Kola Babalola,Sultan Abdul-Jawad,John Cason,Christine Mant,Jeffrey Seow,Carl Graham,Katie J. Doores,Francesca Di Rosa,Jonathan D. Edgeworth,Manu Shankar-Hari,Manu Shankar-Hari,Adrian Hayday,Adrian Hayday +58 more
TL;DR: A core peripheral blood immune signature is identified across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous and sheds light into the pathogenesis and clinical progression of the disease.
Journal ArticleDOI
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Donghyuk Shin,Donghyuk Shin,Rukmini Mukherjee,Diana Grewe,Denisa Bojkova,Kheewoong Baek,Anshu Bhattacharya,Laura Schulz,Marek Widera,Ahmad Reza Mehdipour,Georg Tascher,Paul P. Geurink,Alexander Wilhelm,Gerbrand J. van der Heden van Noort,Huib Ovaa,Stefan Müller,Klaus-Peter Knobeloch,Krishnaraj Rajalingam,Brenda A. Schulman,Jindrich Cinatl,Gerhard Hummer,Gerhard Hummer,Sandra Ciesek,Sandra Ciesek,Ivan Dikic +24 more
TL;DR: Biochemical, structural and functional studies on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease PLpro reveal that it regulates host antiviral responses by preferentially cleaving the ubiquitin-like interferon-stimulated gene 15 protein (ISG15) and identify this protease as a potential therapeutic target for coronav virus disease 2019 (COVID-19).
Journal ArticleDOI
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Mehdi Bouhaddou,Danish Memon,Bjoern Meyer,Kris M. White,Veronica V. Rezelj,Miguel Correa Marrero,Benjamin J. Polacco,James E. Melnyk,Svenja Ulferts,Robyn M. Kaake,Jyoti Batra,Alicia L. Richards,Erica Stevenson,David E. Gordon,Ajda Rojc,Kirsten Obernier,Jacqueline M. Fabius,Margaret Soucheray,Lisa Miorin,Elena Moreno,Cassandra Koh,Quang Dinh Tran,Alexandra Hardy,Rémy Robinot,Thomas Vallet,Benjamin E. Nilsson-Payant,Claudia Hernandez-Armenta,Alistair Dunham,Sebastian Weigang,Julian Knerr,Maya Modak,Diego Quintero,Yuan Zhou,Aurelien Dugourd,Alberto Valdeolivas,Trupti Patil,Qiongyu Li,Ruth Hüttenhain,Merve Cakir,Monita Muralidharan,Minkyu Kim,Gwendolyn M. Jang,Beril Tutuncuoglu,Joseph Hiatt,Jeffrey Z. Guo,Jiewei Xu,Sophia Bouhaddou,Christopher J.P. Mathy,Anna Gaulton,Emma J. Manners,Eloy Felix,Ying Shi,Marisa Goff,Jean K. Lim,Timothy McBride,Michael C. O’Neal,Yiming Cai,Jason C.J. Chang,David J. Broadhurst,Saker Klippsten,Emmie de Wit,Andrew R. Leach,Tanja Kortemme,Brian K. Shoichet,Melanie Ott,Julio Saez-Rodriguez,Benjamin R. tenOever,R. Dyche Mullins,Elizabeth R. Fischer,Georg Kochs,Robert Grosse,Adolfo García-Sastre,Marco Vignuzzi,Jeffery R. Johnson,Kevan M. Shokat,Danielle L. Swaney,Pedro Beltrao,Nevan J. Krogan +77 more
TL;DR: A quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells reveals dramatic rewiring of phosphorylation on host and viral proteins, revealing potential COVID-19 therapies.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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