Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Interferon β-1a (IFNβ-1a) in COVID-19 patients (INTERCOP): study protocol for a randomized controlled trial
Emanuele Bosi,Carlo Bosi,Patrizia Rovere Querini,Nicasio Mancini,Giliola Calori,Annalisa Ruggeri,Cecilia Canzonieri,Luciano Callegaro,Massimo Clementi,Francesco De Cobelli,Massimo Filippi,Marco Bregni +11 more
TL;DR: INTERCOP is the first study to specifically investigate the clinical benefits of IFNβ-1a in COVID-19 patients and potential implications of this trial are multifaceted: should the primary outcome be fulfilled and the treatment be safe, one may envisage that IFN β-1A be used to reduce the infectivity of patients with mild-to moderate disease.
Journal ArticleDOI
A Connectivity Map-Based Drug Repurposing Study and Integrative Analysis of Transcriptomic Profiling of SARS-CoV-2 Infection
TL;DR: The results suggest the effectiveness of lansoprazole, folic acid, sulfamonomethoxine, tolnaftate, diclofenamide, halcinonide, saquinavir, metronidazole, ebselen, lidocaine and benzocaine, histone deacetylase (HDAC) inhibitors, heat shock protein 90 (HSP90) inhibitor, and many other clinically approved drugs as potent drugs against COVID
Journal ArticleDOI
Severe SARS-CoV-2 disease in the context of a NF-κB2 loss-of-function pathogenic variant.
Roshini S. Abraham,Joanna M. Marshall,Hye Sun Kuehn,Cesar M. Rueda,Amber Gibbs,Will Guider,Claire Stewart,Sergio D. Rosenzweig,Huanyu Wang,Sophonie Jean,Mark E. Peeples,Mark E. Peeples,Tiffany King,Tiffany King,W. Garrett Hunt,W. Garrett Hunt,Jonathan R. Honegger,Jonathan R. Honegger,Octavio Ramilo,Octavio Ramilo,Peter J. Mustillo,Peter J. Mustillo,Asuncion Mejias,Asuncion Mejias,Monica I Ardura,Monica I Ardura,Masako Shimamura,Masako Shimamura +27 more
TL;DR: The functional consequence and immunological phenotype of a novel NFKB2 LOF variant in a 17y old male patient and the clinical management of SARS-CoV-2 infection in this context are evaluated.
Journal ArticleDOI
Diagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome.
TL;DR: An overview of the underlying immune profile of COVID-19-related CRS as well as laboratory markers for acute diagnosis and chronic follow-up of patients with SARS-CoV-2 and CRS are provided.
Journal ArticleDOI
mRNA-lncRNA Co-Expression Network Analysis Reveals the Role of lncRNAs in Immune Dysfunction during Severe SARS-CoV-2 Infection.
TL;DR: The present study uncovers molecular interactions behind the cytokine storm activation potentially responsible for hyper-inflammatory responses in critical COVID-19 patients.
References
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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