Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell.
Maritza Puray-Chavez,Kyle M. LaPak,Travis P. Schrank,Jennifer L Elliott,Dhaval P. Bhatt,Megan J. Agajanian,Ria Jasuja,Dana Q. Lawson,Keanu Davis,Paul W. Rothlauf,Paul W. Rothlauf,Zhuoming Liu,Heejoon Jo,Nakyung Lee,Kasyap Tenneti,Jenna E. Eschbach,Christian Shema Mugisha,Emily M. Cousins,Erica W. Cloer,Hung R. Vuong,Laura A. VanBlargan,Adam L. Bailey,Pavlo Gilchuk,James E. Crowe,Michael S. Diamond,D. Neil Hayes,Sean P. J. Whelan,Amjad Horani,Steven L. Brody,Dennis Goldfarb,M. Ben Major,Sebla B. Kutluay +31 more
TL;DR: In this article, the authors identify human H522 lung adenocarcinoma cells as naturally permissive to SARS-CoV-2 infection despite complete absence of angiotensin-converting enzyme 2 (ACE2) expression.
Journal ArticleDOI
Can SARS-CoV-2 Virus Use Multiple Receptors to Enter Host Cells?
Laura Kate Gadanec,Kristen Renee McSweeney,Tawar Qaradakhi,Benazir Ashiana Ali,Anthony Zulli,Vasso Apostolopoulos +5 more
TL;DR: In this article, a densely glycosylated spike (S) protein, which engages angiotensin-converting enzyme 2 (ACE2) to mediate host cell entry, was shown to exploit additional receptors for infection.
Journal ArticleDOI
Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19.
Carmen Mirabelli,Jesse W Wotring,Charles J. Zhang,Sean M McCarty,Reid Fursmidt,Carla D. Pretto,Yuanyuan Qiao,Yuping Zhang,Tristan Frum,Namrata S Kadambi,Anya T Amin,Teresa R. O’Meara,Jason R. Spence,Jessie Huang,Konstantinos D. Alysandratos,Darrell N. Kotton,Samuel K. Handelman,Christiane E. Wobus,Kevin J. Weatherwax,George A. Mashour,Matthew J. O’Meara,Arul M. Chinnaiyan,Jonathan Z. Sexton +22 more
TL;DR: In this article, the authors developed a quantitative high-throughput screen to identify efficacious agents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the associated disease COVID-19, requires therapeutic interventions that can be rapidly identified and translated to clinical care.
Journal ArticleDOI
Cytokine Storm in COVID-19: Immunopathogenesis and Therapy
Christian Zanza,T. Romenskaya,Alice Chiara Manetti,Francesco Franceschi,Raffaele La Russa,Giuseppe Bertozzi,Aniello Maiese,Gabriele Savioli,G. Volonnino,Yaroslava Longhitano +9 more
TL;DR: Since the onset of the pandemic, numerous agents have been tested in the effort to mitigate the cytokine storm in COVID-19 patients, some of which are effective in reducing mortality, especially in critically ill patients, and are now becoming standards of care, such as glucocorticoids or some cytokine inhibitors.
Journal ArticleDOI
A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells.
Yiliang Wang,Yun Wang,Weisheng Luo,Lianzhou Huang,Ji Xiao,Feng Li,Shurong Qin,Xiaowei Song,Yanting Wu,Qiongzhen Zeng,Fujun Jin,Wang Yifei +11 more
TL;DR: It is suggested that ACE2 protein is mainly expressed in the small intestine, kidney, gallbladder, and testis, while the abundance of which in brain-associated tissues and blood common cells is low, which may indicate the risk of different human organs vulnerable to SARS-CoV-2 infection.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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