Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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IL-6-based mortality risk model for hospitalized patients with COVID-19.
Rocío Laguna-Goya,Alberto Utrero-Rico,Paloma Talayero,Maria Lasa-Lazaro,Angel Ramirez-Fernandez,Laura Naranjo,Alejandro Segura-Tudela,Oscar Cabrera-Marante,Edgar Rodriguez de Frias,Rocío García-García,Mario Fernández-Ruiz,José María Aguado,Joaquin Martinez-Lopez,Elena Ana Lopez,Mercedes Catalán,Antonio Serrano,Estela Paz-Artal +16 more
TL;DR: This mortality risk model allows early risk stratification of hospitalized patients with COVID-19 before the appearance of obvious signs of clinical deterioration, and it can be used as a tool to guide clinical decision making.
Journal ArticleDOI
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions
Michael R. Filbin,Michael R. Filbin,Arnav Mehta,Alexis M. Schneider,Kyle R. Kays,Jamey R. Guess,Matteo Gentili,Bánk G. Fenyves,Bánk G. Fenyves,Nicole C. Charland,Anna L.K. Gonye,Anna L.K. Gonye,Irena Gushterova,Irena Gushterova,Hargun K. Khanna,Thomas J. LaSalle,Thomas J. LaSalle,Kendall M. Lavin-Parsons,Brendan M. Lilley,Carl L. Lodenstein,Kasidet Manakongtreecheep,Kasidet Manakongtreecheep,Justin D. Margolin,Brenna N. McKaig,Maricarmen Rojas-Lopez,Brian C. Russo,Nihaarika Sharma,Nihaarika Sharma,Jessica Tantivit,Jessica Tantivit,Molly Thomas,Robert E. Gerszten,Robert E. Gerszten,Graham Heimberg,Paul Hoover,Paul Hoover,David J. Lieb,Brian M. Lin,Debby Ngo,Debby Ngo,Karin Pelka,Miguel Reyes,Christopher Smillie,Avinash Waghray,Thomas E. Wood,Amanda S. Zajac,Lori L. Jennings,Ida Grundberg,Roby P. Bhattacharyya,Roby P. Bhattacharyya,Blair A. Parry,Alexandra-Chloé Villani,Moshe Sade-Feldman,Moshe Sade-Feldman,Nir Hacohen,Nir Hacohen,Marcia B. Goldberg +56 more
TL;DR: In this paper, the authors analyzed several thousand plasma proteins longitudinally in 306 severe coronavirus disease 2019 (COVID-19) patients and 78 symptomatic controls, uncovering immune and non-immune proteins linked to COVID-2019.
Journal ArticleDOI
Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients.
Constantin J. Thieme,Moritz Anft,Krystallenia Paniskaki,Arturo Blazquez-Navarro,Arturo Blazquez-Navarro,Adrian Doevelaar,Felix S. Seibert,Bodo Hoelzer,Margarethe Konik,Marc M. Berger,Thorsten Brenner,Clemens B. Tempfer,Carsten Watzl,Toni Luise Meister,Stephanie Pfaender,Eike Steinmann,Sebastian Dolff,Ulf Dittmer,Timm H. Westhoff,Oliver Witzke,Ulrik Stervbo,Toralf Roch,Toralf Roch,Nina Babel,Nina Babel +24 more
TL;DR: The data disprove the hypothesis of insufficient SARS-CoV-2-reactive immunity in critical COVID-19 and indicates that activation of differentiated memory effector T cells could cause hyper-reactivity and immunopathogenesis in critical patients.
Journal ArticleDOI
Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data.
Tiphanie P. Vogel,Karina A. Top,Christos Karatzios,David C. Hilmers,Lorena I. Tapia,Pamela Moceri,Lisa Giovannini-Chami,Nicholas Wood,Rebecca E. Chandler,Nicola P. Klein,Elizabeth P. Schlaudecker,M. Cecilia Poli,Eyal Muscal,Flor M. Munoz +13 more
TL;DR: The Brighton Collaboration case definition of Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A) was developed by topic experts in the context of active development of vaccines for SARS-CoV-2 as discussed by the authors.
Journal ArticleDOI
Senolytics reduce coronavirus-related mortality in old mice.
Christina D. Camell,Matthew J. Yousefzadeh,Yi Zhu,Larissa G.P. Langhi Prata,Matthew A. Huggins,Mark Pierson,Lei Zhang,Ryan D. O’Kelly,Tamar Pirtskhalava,Pengcheng Xun,Keisuke Ejima,Ailing Xue,Utkarsh Tripathi,Jair Machado Espindola-Netto,Nino Giorgadze,Elizabeth J. Atkinson,Christina L. Inman,Kurt O. Johnson,Stephanie H. Cholensky,Timothy W. Carlson,Nathan K. LeBrasseur,Sundeep Khosla,M. Gerard O'Sullivan,David B. Allison,Stephen C. Jameson,Alexander Meves,Ming Li,Y. S. Prakash,Sergio E. Chiarella,Sara E. Hamilton,Tamara Tchkonia,Laura J. Niedernhofer,James L. Kirkland,Paul D. Robbins +33 more
TL;DR: In this paper, the authors demonstrate that senescent cells become hyper-inflammatory in response to pathogen-associated molecular patterns (PAMPs), including SARS-CoV-2 spike protein-1, increasing expression of viral entry proteins and reducing antiviral gene expression in non-SnCs through a paracrine mechanism.
References
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
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Fast gapped-read alignment with Bowtie 2
TL;DR: Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
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ggplot2: Elegant Graphics for Data Analysis
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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