Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Journal ArticleDOI
Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms.
Alexandra E. Livanos,Divya Jha,Francesca Cossarini,Ana S. Gonzalez-Reiche,Minami Tokuyama,Teresa Aydillo,Tommaso Lorenzo Parigi,Mark S. Ladinsky,Irene Ramos,Katie A. Dunleavy,Brian T. Lee,Rebekah E. Dixon,Steven T. Chen,Gustavo Martinez-Delgado,Satish Nagula,Emily A. Bruce,Huaibin M. Ko,Benjamin S. Glicksberg,Girish N. Nadkarni,Elisabet Pujadas,Jason Reidy,Steven Naymagon,Ari Grinspan,Jawad Ahmad,Michael Tankelevich,Yaron Bram,Ronald E. Gordon,Keshav Sharma,Jane Houldsworth,Graham J. Britton,Alice Chen-Liaw,Matthew P. Spindler,Tamar Plitt,Pei Wang,Andrea Cerutti,Jeremiah J. Faith,Jean-Frederic Colombel,Ephraim Kenigsberg,Carmen Argmann,Miriam Merad,Sacha Gnjatic,Noam Harpaz,Silvio Danese,Carlos Cordon-Cardo,Adeeb Rahman,Robert E. Schwartz,Nikhil A. Kumta,Alessio Aghemo,Pamela J. Bjorkman,Francesca Petralia,Harm van Bakel,Adolfo García-Sastre,Saurabh Mehandru +52 more
TL;DR: In this article, the authors investigated intestinal infection with SARS-CoV-2, its effect on pathogenesis, and clinical significance, and found a significant reduction in disease severity and mortality in patients presenting with GI symptoms that was independent of sex, age, and comorbid illnesses.
Journal ArticleDOI
The Emerging Role of Vitamin C in the Prevention and Treatment of COVID-19.
Anitra C. Carr,Sam Rowe +1 more
TL;DR: Due to the excellent safety profile, low cost, and potential for rapid upscaling of production, administration of vitamin C to patients with hypovitaminosis C and severe respiratory infections, e.g., COVID-19, appears warranted.
Journal ArticleDOI
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity.
Melissa Saichi,Maha Zohra Ladjemi,Sarantis Korniotis,Christophe Rousseau,Zakaria Ait Hamou,Lucile Massenet-Regad,Lucile Massenet-Regad,Elise Amblard,Floriane Noël,Y. Marie,Y. Marie,Delphine Bouteiller,Jasna Medvedovic,Frédéric Pène,Vassili Soumelis +14 more
TL;DR: In this paper, the authors performed single-cell RNA-sequencing to establish a high-resolution map of blood antigen-presenting cells (APCs) in 15 patients with moderate or severe COVID-19 pneumonia, at day 1 and day 4 post admission to intensive care unit or pulmonology department.
Journal ArticleDOI
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.
Na Li,Hui Hui,Bill Bray,Gwendolyn Gonzalez,Mark Zeller,Kristian G. Anderson,Rob Knight,Davey M. Smith,Yinsheng Wang,Aaron F. Carlin,Tariq M. Rana +10 more
TL;DR: In this paper, the authors investigated m6A modification of the SARS-CoV-2 gene in regulating the host cell innate immune response and found that depletion of the host-cell m6a methyltransferase METTL3 decreases m6As levels in SARS and host genes, and reduction in viral RNA increases RIGI binding and subsequently enhances the downstream innate immune signaling pathway and inflammatory gene expression.
Posted ContentDOI
Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids
Yuling Han,Liuliu Yang,Xiaohua Duan,Fuyu Duan,Benjamin E. Nilsson-Payant,Tomer M. Yaron,Pengfei Wang,Xuming Tang,Tuo Zhang,Zeping Zhao,Yaron Bram,David Redmond,Sean Houghton,Duc T. Nguyen,Dong Xu,Xing Wang,Skyler Uhl,Yaoxing Huang,Jared L. Johnson,Jenny Xiang,Hui Wang,Fong Cheng Pan,Lewis C. Cantley,Benjamin R. tenOever,David D. Ho,Todd Evans,Robert E. Schwartz,Huanhuan Joyce Chen,Shuibing Chen +28 more
TL;DR: It is demonstrated that hPSC-derived lung cells infected by SARS-CoV-2 can model human COVID-19 disease and provide a valuable resource to screen for FDA-approved drugs that might be repurposed and should be considered for CO VID-19 clinical trials.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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