Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
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Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies.
Jérémy Dufloo,Jérémy Dufloo,Ludivine Grzelak,Ludivine Grzelak,Isabelle Staropoli,Yoann Madec,Laura Tondeur,François Anna,Stéphane Pelleau,Aurélie Wiedemann,Cyril Planchais,Julian Buchrieser,Rémy Robinot,Marie-Noëlle Ungeheuer,Hugo Mouquet,Pierre Charneau,Michael T. White,Yves Levy,Bruno Hoen,Arnaud Fontanet,Olivier Schwartz,Olivier Schwartz,Timothée Bruel,Timothée Bruel +23 more
TL;DR: Overall, asymptomatic SARS-CoV-2 infection elicits polyfunctional antibodies neutralizing the virus and targeting infected cells, and functions of anti-Spike antibodies have similar kinetics of induction and contraction.
Journal ArticleDOI
Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy.
TL;DR: In this paper, the authors highlight kinases that are associated with coronavirus infections and their inhibitors with antiviral and potentially anti-inflammatory, cytokine-suppressive, or antifibrotic activity.
Journal ArticleDOI
Immune evasion of SARS-CoV-2 from interferon antiviral system.
TL;DR: In this article, the authors summarize and discuss the strategies of SARS-CoV-2 for evasion of innate immunity (particularly the antiviral IFN responses), understanding of which will facilitate not only the elucidation of infection and pathogenesis but also the development of antiviral intervention therapies.
Journal ArticleDOI
A cytokine super cyclone in COVID-19 patients with risk factors: the therapeutic potential of BCG immunization.
TL;DR: In this paper, the authors discuss the pathogenic consequences of the cytokine storm and its relationship with COVID-19 associated risk factors, and evaluate the antiviral immune responses provided by BCG vaccination and the potential role of trained immunity in early protection against SARS-CoV2.
Journal ArticleDOI
COVID-19 in patients with multiple sclerosis undergoing disease-modifying treatments.
TL;DR: In this article, the authors reviewed available information on how infections by human coronaviruses affect the immune system in untreated subjects and in patients affected by MS treated with drugs which modulate the immune systems.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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