Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Novel SARS-CoV-2 encoded small RNAs in the passage to humans
Gabriela Alejandra Merino,Gabriela Alejandra Merino,Jonathan Raad,Leandro A. Bugnon,Cristian Ariel Yones,Laura Kamenetzky,Laura Kamenetzky,Juan Daniel Claus,Federico Ariel,Diego H. Milone,Georgina Stegmayer +10 more
TL;DR: The results suggest that the recent acquisition of novel miRNAs-like sequences in the SARS-CoV-2 genome may have contributed to modulate the transcriptional reprogramming of the new host upon infection.
Posted ContentDOI
Modulating the transcriptional landscape of SARS-CoV-2 as an effective method for developing antiviral compounds
Daisy A. Hoagland,Daniel J.B. Clarke,Rasmus Møller,Yuling Han,Liuliu Yang,Megan L. Wojciechowicz,Alexander Lachmann,Kasopefoluwa Y. Oguntuyo,Christian S. Stevens,Brendan Lee,Shuibing Chen,Avi Ma'ayan,Benjamin R. tenOever +12 more
TL;DR: The successful identification of compounds that display efficacy in blocking SARS-CoV-2 replication based on their ability to counteract the virus-induced transcriptional landscape are demonstrated.
Journal ArticleDOI
IL-6 and IL-10 are associated with disease severity and higher comorbidity in adults with COVID-19.
Rafael Luís Luporini,Joice Margareth de Almeida Rodolpho,Lauro T. Kubota,Ana Carolina Baptista Moreno Martin,Márcia Regina Cominetti,Fernanda de Freitas Anibal,Henrique Pott-Junior +6 more
TL;DR: In this article, the authors assess circulating levels of inflammatory cytokines in adult patients who were hospitalized with COVID-19 and stratified according to age (older or younger than 65 years) aiming to explore associations between these markers of inflammation and comorbidities.
Journal ArticleDOI
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.
C.A. Brosey,Jerry H. Houl,Panagiotis Katsonis,Lakshitha P.F. Balapiti-Modarage,Shobanbabu Bommagani,Andy Arvai,Davide Moiani,Albino Bacolla,Todd M. Link,Leslie S. Warden,Olivier Lichtarge,Darin E. Jones,Zamal Ahmed,John A. Tainer,John A. Tainer +14 more
TL;DR: In this article, the structure of CoV-2 MacroD-like macrodomain (Mac1) was solved from non-structural protein 3 and applied structural and sequence-based genetic tracing, including newly determined A. pompejana MacroD2 and GDAP2 amino acid sequences.
Journal ArticleDOI
Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids.
Henkie Isahwan Ahmad Mulyadi Lai,Shih Jie Chou,Yueh Chien,Ping Hsing Tsai,Chian Shiu Chien,Chih Chien Hsu,Ying Chun Jheng,Mong Lien Wang,Shih Hwa Chiou,Yu Bai Chou,De Kuang Hwang,Tai Chi Lin,Shih-Jen Chen,Yi Ping Yang +13 more
TL;DR: Zhang et al. as mentioned in this paper investigated whether ACE2 expression plays a role in human retinal neurons during SARS-CoV-2 infection and showed that retinal organoids and monolayer cultures endogenously express ACE2 and transmembrane serine protease 2 on the mRNA level.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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