Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19.
Aaron J. Wilk,Madeline J. Lee,Bei Wei,Benjamin Parks,Ruoxi Pi,Giovanny J Martínez-Colón,Thanmayi Ranganath,Nancy Q. Zhao,Shalina Taylor,Winston R. Becker,Stanford Covid Biobank,David Jimenez-Morales,Andra L. Blomkalns,Ruth O'Hara,Euan A. Ashley,Kari C. Nadeau,Samuel Yang,Susan Holmes,Marlene Rabinovitch,Angela J. Rogers,William J. Greenleaf,Catherine A. Blish +21 more
TL;DR: Single-cell profiling demonstrates multifarious dysregulation of innate immune phenotype associated with COVID-19 severity, which is associated with hyperactivation of neutrophils and NK cells, while monocytes take on tolerogenic phenotypes.
Journal ArticleDOI
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.
Bingyu Yan,Tilo Freiwald,Tilo Freiwald,Daniel Chauss,Luopin Wang,Erin E. West,Carmen Mirabelli,Charles J. Zhang,Eva-Maria Nichols,Nazish Malik,Richard Gregory,Marcus Bantscheff,Sonja Ghidelli-Disse,Martin Kolev,Tristan Frum,Jason R. Spence,Jonathan Z. Sexton,Konstantinos D. Alysandratos,Konstantinos D. Alysandratos,Darrell N. Kotton,Darrell N. Kotton,Stefania Pittaluga,Jack A. Bibby,Nathalie Niyonzima,Matthew R. Olson,Shahram Kordasti,Shahram Kordasti,Didier Portilla,Didier Portilla,Christiane E. Wobus,Arian Laurence,Michail S. Lionakis,Claudia Kemper,Claudia Kemper,Behdad Afzali,Majid Kazemian +35 more
TL;DR: In this paper, the authors found that the complement system was one of the intracellular pathways most highly induced by SARS-CoV-2 infection in lung epithelial cells.
Journal ArticleDOI
COVID-19: Complement, Coagulation, and Collateral Damage.
TL;DR: A summary of CO VID-19 is provided and complement’s role in COVID-19 acute respiratory distress syndrome and coagulopathy is reviewed, suggesting that the complement system plays a key role in this inflammatory reaction.
Journal ArticleDOI
Cytokine profile and disease severity in patients with COVID-19.
TL;DR: The data suggest that TGF-β can be used as a predictive factor of disease severity in patients with COVID-19, and interferon-γ and IL-17 are involved in inducing and mediating proinflammatory responses.
Posted ContentDOI
Immunological memory to SARS-CoV-2 assessed for greater than six months after infection
Jennifer M. Dan,Jennifer M. Dan,Jose Mateus,Yu Kato,Kathryn M. Hastie,Esther Dawen Yu,Caterina E. Faliti,Alba Grifoni,Sydney I. Ramirez,Sydney I. Ramirez,Sonya Haupt,April Frazier,Catherine Nakao,Catherine Nakao,Vamseedhar Rayaprolu,Stephen A. Rawlings,Bjoern Peters,Bjoern Peters,Florian Krammer,Viviana Simon,Erica Ollmann Saphire,Erica Ollmann Saphire,Davey M. Smith,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Shane Crotty,Shane Crotty +27 more
TL;DR: It is observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics, and Spike IgG was relatively stable over 6+ months.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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