Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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SARS-CoV-2 Productively Infects Human Gut Enterocytes
Mart M. Lamers,Joep Beumer,Jelte van der Vaart,Kèvin Knoops,Jens Puschhof,Tim I Breugem,Raimond B. G. Ravelli,J. Paul van Schayck,Anna Z Mykytyn,Hans Duimel,Elly van Donselaar,Samra Riesebosch,Helma J.H. Kuijpers,Debby Schipper,Willine J. van de Wetering,Miranda de Graaf,Marion Koopmans,Edwin Cuppen,Peter J. Peters,Bart L. Haagmans,Hans Clevers +20 more
TL;DR: It is concluded that intestinal epithelium supports SARS-CoV-2 replication and is associated with strong induction of a generic viral response program.
Journal ArticleDOI
Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities.
TL;DR: It is demonstrated that biological sex is a fundamental variable of critical relevance to the authors' mechanistic understanding of SARS-CoV-2 infection and the pursuit of effective COVID-19 preventative and therapeutic strategies.
Journal ArticleDOI
The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?
TL;DR: What is known about the role of the innate immune system during SARS-CoV-2 infection is discussed, directions for future studies are suggested, and proposed COVID-19 immunomodulating therapeutics are evaluated.
Journal ArticleDOI
COVID-19: A review of therapeutic strategies and vaccine candidates.
TL;DR: The purpose of this article is to review the most up-to-date published data regarding both the leading pharmacological therapies undergoing clinical trials and vaccine candidates in development to stem the threat of COVID-19.
Journal ArticleDOI
Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia
Andrés Pizzorno,Blandine Padey,Thomas Julien,Sophie Trouillet-Assant,Sophie Trouillet-Assant,Aurélien Traversier,Elisabeth Errazuriz-Cerda,Julien Fouret,Julia Dubois,Alexandre Gaymard,François Xavier Lescure,François Xavier Lescure,Victoria Dulière,Pauline Brun,Samuel Constant,Julien Poissy,Bruno Lina,Yazdan Yazdanpanah,Yazdan Yazdanpanah,Olivier Terrier,Manuel Rosa-Calatrava +20 more
TL;DR: This work uses reconstituted human airway epithelia to isolate and characterize the viral infection kinetics, tissue-level remodeling of the cellular ultrastructure, and transcriptional early immune signatures induced by SARS-CoV-2 in a physiologically relevant model and provides evidence in human-derived tissues on the antiviral efficacy of remdesivir monotherapy.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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