Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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The cytokine storm and thyroid hormone changes in COVID-19.
TL;DR: In this article, the authors summarized available studies regarding thyroid function alterations in patients with COVID-19 and to overview the possible physio-pathological explanations for the thyroid dysfunction.
Journal ArticleDOI
COVID-19: Infection or Autoimmunity.
TL;DR: There is potential use of T cell depleting therapies and possibly anti-CD20 therapy for COVID-19 and clinical research using these medications is warranted and review of the basic science of other viral induced autoimmune disorders may give clues as to why immunosuppressive and immunomodulating regimens now appear to have some efficacy.
Journal ArticleDOI
Increased Angiotensin-Converting Enzyme 2 and Loss of Alveolar Type II Cells in COVID-19-related Acute Respiratory Distress Syndrome.
Ludovic Gerard,Marylène Lecocq,Caroline Bouzin,Delphine Hoton,Gregory Schmit,Joao Pinto Pereira,Virginie Montiel,Thomas Plante-Bordeneuve,Pierre-François Laterre,Charles Pilette +9 more
TL;DR: In this paper, ACE2 (angiotensin-converting enzyme 2), the entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is expressed in type 2 alveolar epithelial cells (AT2) that m...
Posted ContentDOI
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
Maritza Puray-Chavez,Kyle M. LaPak,Travis P. Schrank,Jennifer L Elliott,Dhaval P. Bhatt,Megan J. Agajanian,Ria Jasuja,Dana Q. Lawson,Keanu Davis,Paul W. Rothlauf,Heejoon Jo,Nakyung Lee,Kasyap Tenneti,Jenna E. Eschbach,Christian Shema Mugisha,Hung R. Vuong,Adam L. Bailey,D. Neil Hayes,Sean P. J. Whelan,Amjad Horani,Steven L. Brody,Dennis Goldfarb,M. Ben Major,Sebla B. Kutluay +23 more
TL;DR: In this paper, a panel of 10 cell lines, with variable expression levels of ACE2 and TMPRSS2 were infected with SARS-CoV-2 strain 2019-nCoV/USA-WA1/2020.
Journal ArticleDOI
Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy
Lissenya B. Argueta,Lauretta A. Lacko,Yaron Bram,Takuya Tada,Lucia Carrau,André F. Rendeiro,Tuo Zhang,Skyler Uhl,Brienne Lubor,Vasuretha Chandar,Cristiane Damas Gil,Wei Na Zhang,Brittany J. Dodson,Jeroen Bastiaans,Malavika Prabhu,Sean Houghton,David Redmond,Christine M. Salvatore,Yawei J. Yang,Olivier Elemento,Rebecca N. Baergen,Benjamin R. tenOever,Nathaniel R. Landau,Shuibing Chen,Robert E. Schwartz,Heidi Stuhlmann +25 more
TL;DR: In this article , the effect of SARS-CoV-2 infection on placental function is not well understood, but placentas from two mothers with symptomatic COVID-19 whose pregnancies resulted in adverse outcomes for the fetuses contained high levels of viral Alpha variant RNA.
References
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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