Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Host-Virus Chimeric Events in SARS-CoV-2-Infected Cells Are Infrequent and Artifactual.
Bingyu Yan,Srishti Chakravorty,Carmen Mirabelli,Luopin Wang,Jorge L Trujillo-Ochoa,Daniel Chauss,Dhaneshwar Kumar,Dhaneshwar Kumar,Michail S. Lionakis,Matthew R. Olson,Christiane E. Wobus,Behdad Afzali,Majid Kazemian +12 more
TL;DR: The findings indicate that HVC events observed in RNA-sequencing libraries from SARS-CoV2 infected cells are extremely rare and are likely artifacts arising from either random template switching of reverse-transcriptase and/or sequence alignment errors.
Posted ContentDOI
Functional immune mapping with deep-learning enabled phenomics applied to immunomodulatory and COVID-19 drug discovery
Michael F. Cuccarese,Berton A. Earnshaw,Katie Heiser,Ben Fogelson,Chadwick T. Davis,Peter F. McLean,Hannah B. Gordon,Kathleen-Rose Skelly,Fiona L. Weathersby,Vlad Rodic,Ian K. Quigley,Elissa D. Pastuzyn,Brandon M. Mendivil,Nathan H. Lazar,Carl A. Brooks,Joseph Carpenter,Brandon L. Probst,Pamela Jacobson,Seth W. Glazier,Jes Ford,James D. Jensen,Nicholas D. Campbell,Michael A. Statnick,Adeline S. Low,Kirk R. Thomas,Anne E. Carpenter,Sharath S. Hegde,Ronald W. Alfa,Mason L. Victors,Imran S. Haque,Yolanda T. Chong,Christopher C. Gibson +31 more
TL;DR: Deep-learning-driven analysis of cellular morphology is applied to develop a scalable “phenomics” platform and its ability to identify dose-dependent, high-dimensional relationships among and between immunomodulators, toxins, pathogens, genetic perturbations, and small and large molecules at scale is demonstrated.
Journal ArticleDOI
Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome.
Kiran Iqbal Masood,Maliha Yameen,Javeria Ashraf,Saba Shahid,Syed Faisal Mahmood,Asghar Nasir,Nosheen Nasir,Bushra Jamil,Najia Karim Ghanchi,Iffat Khanum,Safina Abdul Razzak,Akbar Kanji,Rabia Hussain,Martin E. Rottenberg,Zahra Hasan +14 more
TL;DR: In this paper, the authors used a blood transcriptome approach to study biomarkers associated with differing severity of SARS-CoV-2 infection, comparing severe and mild Symptomatic disease with Asymptomatic COVID-19 and uninfected Controls.
Journal ArticleDOI
N-Acetylcysteine and Hydrogen Sulfide in Coronavirus Disease 2019.
Arno R. Bourgonje,Annette K. Offringa,Larissa E. van Eijk,Amaal Eman Abdulle,Jan-Luuk Hillebrands,Peter H. J. van der Voort,Harry van Goor,Ed J van Hezik +7 more
TL;DR: In this article, the role of hydrogen sulfide (H2S) in the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was investigated.
Journal ArticleDOI
Severe COVID-19 Lung Infection in Older People and Periodontitis
TL;DR: In this article, a review focused on how the dissemination of periodontal bacteria into the lungs could aggravate age-related senescent cell accumulation and facilitate more efficient SARS-CoV-2 cell attachment and replication.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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