Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Immunogenetic Association Underlying Severe COVID-19.
TL;DR: Together, key genes unraveled by genetic profiling may provide targets for precisely early risk diagnosis and prophylactic design to relieve severe COVID-19.
Journal ArticleDOI
Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infection.
Babajan Banaganapalli,Nuha Alrayes,Zuhier Awan,Faten A. S. Alsulaimany,Abdulhakeem S. Alamri,Ramu Elango,Zubbair Malik,Noor Ahmad Shaik +7 more
TL;DR: In this article, a multilevel robust computational analysis was undertaken for viral genetic sequence alignment, phylogram construction, genome-wide transcriptome data interpretation of virus-infected lung tissues, miRNA mapping, and functional biology networking.
Journal ArticleDOI
JAK-STAT Pathway: A Novel Target to Tackle Viral Infections
TL;DR: In this article, the authors review the diversity of strategies that viruses have evolved to interfere with JAK-STAT signaling, stressing the relevance of this pathway as a putative antiviral target.
Posted ContentDOI
Type III interferons disrupt the lung epithelial barrier upon viral recognition.
Achille Broggi,Sreya Ghosh,Benedetta Sposito,Benedetta Sposito,Roberto Spreafico,Fabio Balzarini,Fabio Balzarini,Antonino Lo Cascio,Antonino Lo Cascio,Nicola Clementi,Maria De Santis,Nicasio Mancini,Francesca Granucci,Ivan Zanoni,Ivan Zanoni +14 more
TL;DR: It is demonstrated that type III interferons produced by dendritic cells in the lung in response to viral recognition cause barrier damage and compromise the host tissue tolerance, giving a strong mandate to rethink the pathophysiological roles of this group of interferONS.
Journal ArticleDOI
Animal models in SARS-CoV-2 research
TL;DR: The main animal models that have had a key role in understanding the immune and viral dynamics of SARS-CoV-2 have been discussed in this article , where the authors discuss the main animals that have played key roles in their understanding.
References
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ggplot2: Elegant Graphics for Data Analysis
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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