Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
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SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release
Caroline Junqueira,Angela Crespo,Shahin Ranjbar,M. Lewandrowski,J. Ingber,L. B. de Lacerda,Blair Parry,Sagi Ravid,Sarah Clark,F. Ho,Setu M. Vora,Valerie Leger,Caroline Beakes,Justin D. Margolin,N. Russell,Kyle R. Kays,Lee Gehrke,Upasana Das Adhikari,Lauren A. Henderson,Erin Janssen,Douglas S. Kwon,Chris Sander,Jonathan Abraham,Michael Filbin,Marcia B. Goldberg,Hao Wu,Gautam Mehta,Steven Bell,Anne E. Goldfeld,Judy Lieberman +29 more
TL;DR: In this paper, expression quantitative trait loci (eQTLs) linked to higher gasdermin D (GSDMD) expression increase the risk of severe COVID-19 disease (odds ratio, 1.3, p<0.005).
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Investigation of COVID-19 comorbidities reveals genes and pathways coincident with the SARS-CoV-2 viral disease.
Mary E. Dolan,David P. Hill,Gaurab Mukherjee,Monica S. McAndrews,Elissa J. Chesler,Judith A. Blake +5 more
TL;DR: A bioinformatics analysis of COVID-19 comorbidity-associated gene sets revealed significant enrichment for immune system phenotypes and for cardiovascular-related phenotypes, which might point to alleles and phenotypes in mouse models that could be evaluated for clues to CO VID-19 severity.
Journal ArticleDOI
Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID-19 Cytokine Storm.
Qian-Fang Meng,Rui Tian,Haiyi Long,Xianjia Wu,Jialin Lai,Olga Zharkova,Jiong-Wei Wang,Xiaoyuan Chen,Lang Rao +8 more
TL;DR: In this paper, potential mechanisms of COVID-19 cytokine storm are first discussed, and relevant therapeutic strategies and ongoing clinical trials are then reviewed, and recent research involving emerging biomaterials for improving antibody-based and broad-spectrum cytokine neutralization is summarized.
Journal ArticleDOI
RdRp inhibitors and COVID-19: Is molnupiravir a good option?
TL;DR: In this article , the authors discuss the promising application of RNA-dependent RNA polymerase (RdRp) inhibitors, previously approved or currently being tested in human clinical trials, in the treatment of RNA virus infections.
Journal ArticleDOI
Dynamics of SARS-CoV-2 shedding in the respiratory tract depends on the severity of disease in COVID-19 patients.
Dieter Munker,Andreas Osterman,Andreas Osterman,Hans Stubbe,Maximilian Muenchhoff,Maximilian Muenchhoff,Tobias Veit,Tobias Weinberger,Michaela Barnikel,Jan-Niclas Mumm,Katrin Milger,Elham Khatamzas,Sarah Klauss,Clemens Scherer,Johannes C. Hellmuth,Clemens Giessen-Jung,Michael Zoller,Tobias Herold,Stephanie Susanne Stecher,Enrico N. De Toni,Christian Schulz,Nikolaus Kneidinger,Oliver T. Keppler,Jürgen Behr,Julia Mayerle,S Munker +25 more
TL;DR: In this paper, the dynamics of SARS-CoV-2 shedding relative to disease severity were investigated in 92 patients with diagnosed COVID-19, showing that viral shedding does not differ significantly between severe and non-severe cases upon admission to the hospital.
References
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Journal ArticleDOI
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
Journal ArticleDOI
Fast gapped-read alignment with Bowtie 2
TL;DR: Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
Book
ggplot2: Elegant Graphics for Data Analysis
TL;DR: This book describes ggplot2, a new data visualization package for R that uses the insights from Leland Wilkisons Grammar of Graphics to create a powerful and flexible system for creating data graphics.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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