Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19.
Younes Zaid,Étienne Doré,Isabelle Dubuc,Anne Sophie Archambault,Olivier Flamand,Michel Laviolette,Nicolas Flamand,Eric Boilard,Louis Flamand +8 more
TL;DR: In this article, the authors analyzed and compared the plasma and bronchoalveolar lavage (BAL) fluids of patients with severe COVID-19 (n = 45) for the presence of cytokines and lipid mediators of inflammation (LMIs).
Posted ContentDOI
The active lung microbiota landscape of COVID-19 patients
TL;DR: Insight is provided into the active microbiota in the lungs of COVID-19 patients and will contribute to the understanding of the infection mechanism of SARS-CoV-2 and the treatment of the disease and complications.
Journal ArticleDOI
Network perturbation analysis in human bronchial epithelial cells following SARS-CoV2 infection.
Giuseppe Nunnari,Cristina Sanfilippo,Paola Castrogiovanni,Rosa Imbesi,Giovanni Li Volti,Ignazio Barbagallo,Giuseppe Musumeci,Michelino Di Rosa +7 more
TL;DR: Overall, lung involvement and RDS could be generated by the activation and down regulation of diverse gene pathway involving respiratory cilia and muscle contraction, apoptotic phenomena, matrix destructuration, collagen deposition, neutrophil and macrophages recruitment.
Journal ArticleDOI
Immunoinflammatory, Thrombohaemostatic, and Cardiovascular Mechanisms in COVID-19.
Selin Gencer,Michael Lacy,Dorothee Atzler,Emiel P. C. van der Vorst,Yvonne Döring,Yvonne Döring,Christian Weber +6 more
TL;DR: The mechanisms that may explain how viral entry and activation of endothelial cells by severe acute respiratory syndrome coronavirus 2 can give rise to a series of events including systemic inflammation, thrombosis, and microvascular dysfunction are surveyed.
Posted ContentDOI
Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro
Nir Drayman,Krysten A. Jones,Sarra-Anne Azizi,Heather M. Froggatt,Kemin Tan,Kemin Tan,Natalia Maltseva,Siquan Chen,Vlad Nicolaescu,Steve Dvorkin,Kevin Furlong,Rahul S. Kathayat,Mason R Firpo,Vincent Mastrodomenico,Emily A. Bruce,Madaline M. Schmidt,Robert Jedrzejczak,Robert Jedrzejczak,Miguel Ángel Muñoz-Alía,Brooke Schuster,Vishnu Nair,Jason Botten,Christopher B. Brooke,Susan C. Baker,Bryan C. Mounce,Nicholas S. Heaton,Bryan C. Dickinson,Andrzej Jaochimiak,Andrzej Jaochimiak,Glenn Randall,Savaş Tay +30 more
TL;DR: Results show that masitinib has broad anti-viral activity against two distinct beta-coronavirus and multiple picornaviruses that cause human disease and is a strong candidate for clinical trials to treat SARS-CoV-2 infection.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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