Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
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Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity.
TL;DR: It is argued that maintenance of mitochondrial integrity is essential for adequate innate immune system responses and to blunt mitochondrial modulation by SARS-CoV-2, and markers of mitochondrial functions promising potential biomarkers for Sars-Cov-2 infection risk and severity of outcome are identified.
Journal ArticleDOI
SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation.
Wenjing Wang,Zhuo Zhou,Xia Xiao,Zhongqin Tian,Xiaojing Dong,Conghui Wang,Li Li,Lili Ren,Xiaobo Lei,Zichun Xiang,Jianwei Wang +10 more
TL;DR: Wang et al. as discussed by the authors reported that SARS-CoV-2 nsp12, the viral RNA-dependent RNA polymerase (RdRp), suppresses host antiviral responses.
Journal ArticleDOI
The immune response to SARS-CoV-2 and COVID-19 immunopathology - Current perspectives.
TL;DR: A review of the most recent publications on the immunobiology of SARS-CoV-2, virus interactions with target cells, and host immune responses, and highlight possible associations between deficient innate and acquired immune responses and disease progression and mortality are also addressed.
Journal ArticleDOI
Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly.
TL;DR: Novel targets and potential new strategies for enhancing vaccine responses in older adults are explored, including the use of anti-inflammatory drugs and immunomodulators.
Journal ArticleDOI
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
Fiachra Humphries,Liraz Shmuel-Galia,Zhaozhao Jiang,Ruth Wilson,Philip S. Landis,Sze-Ling Ng,Krishna-Mohan Parsi,René Maehr,John Cruz,Angel I. Morales-Ramos,Ramanjulu Joshi M,John Bertin,G. Scott Pesiridis,Katherine A. Fitzgerald +13 more
TL;DR: In this article, a diamidobenzimidazole compound, diABZI-4, was used to activate STING and inhibited SARS-CoV-2 replication in lung epithelial cells.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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