Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?
TL;DR: In this article, the role of pro-inflammatory cytokines (i.e., IL-1β, IL6, IL8, IL17 and TNFα) in SARS-CoV-2 cytokine release syndrome (CRS) was studied.
Journal ArticleDOI
Coronavirus and Cardiovascular Disease, Myocardial Injury, and Arrhythmia: JACC Focus Seminar.
Gennaro Giustino,Sean Pinney,Anuradha Lala,Vivek Y. Reddy,Hillary A. Johnston-Cox,Jeffrey I. Mechanick,Jonathan L. Halperin,Valentin Fuster +7 more
TL;DR: The mechanisms underlying cardiovascular injury, including that of thromboembolic disease and arrhythmia, are described, and their clinical sequelae are discussed.
Journal ArticleDOI
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity.
Lore Vanderbeke,P. Van Mol,Y. Van Herck,F. De Smet,Stephanie Humblet-Baron,Kimberly Martinod,Asier Antoranz,Ingrid Arijs,Bram Boeckx,Francesca Maria Bosisio,M. Casaer,Dieter Dauwe,W. De Wever,Christophe Dooms,Erwin Dreesen,A. Emmaneel,J. Filtjens,M. Gouwy,Jan Gunst,Greet Hermans,Steven Jansen,Katrien Lagrou,Adrian Liston,N. Lorent,Philippe Meersseman,Toine Mercier,Johan Neyts,J. Odent,Dena Panovska,P. A. Penttila,E. Pollet,Paul Proost,Junbin Qian,K. Quintelier,Jeroen Raes,S. Rex,Yvan Saeys,Jenny Sprooten,Sabine Tejpar,Dries Testelmans,Karin Thevissen,T. Van Buyten,J. Vandenhaute,S. Van Gassen,L. C. Velásquez Pereira,R. Vos,Birgit Weynand,A. Wilmer,Jonas Yserbyt,Abhishek D. Garg,Patrick Matthys,Carine Wouters,D Lambrechts,Els Wauters,Joost Wauters +54 more
TL;DR: A myeloid-driven immunopathology is suggested, in which hyperactivated neutrophils and an ineffective adaptive immune system act as mediators of COVID-19 disease severity.
Journal ArticleDOI
Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology.
Simon J. Cleary,Simon C. Pitchford,Richard T. Amison,Robert Carrington,Robert Carrington,C. Lorena Robaina Cabrera,Mélia Magnen,Mark R. Looney,Elaine Gray,Elaine Gray,Clive P. Page +10 more
TL;DR: There is an urgent need for development of animal models for improved evaluation of efficacy of drugs identified as having potential in the treatment of severe COVID‐19 and ways in which animal models can be adapted to increase their usefulness in research into CO VID‐19 pathogenesis and for assessing potential treatments.
Journal ArticleDOI
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2.
Mark Dittmar,Jae Seung Lee,Kanupriya Whig,Elisha Segrist,Minghua Li,Brinda Kamalia,Lauren Castellana,Kasirajan Ayyanathan,Fabian L. Cardenas-Diaz,Edward E. Morrisey,Rachel Truitt,Wenli Yang,Kellie A. Jurado,Kirandeep Samby,Holly Ramage,David C. Schultz,Sara Cherry +16 more
TL;DR: It is found that the antiviral activity of Cyclosporine is targeting Cyclophilin rather than Calcineurin revealing essential host targets that have the potential for rapid clinical implementation.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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