Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
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Comprehensive Transcriptomic Analysis of COVID-19 Blood, Lung, and Airway
Andrea R. Daamen,Prathyusha Bachali,Katherine A. Owen,Kathryn M. Kingsmore,Erika L. Hubbard,Adam C. Labonte,Robert D. Robl,Sneha Shrotri,Amrie C. Grammer,Peter E. Lipsky +9 more
TL;DR: Results indicate that COVID-19 pathogenesis is driven by populations of myeloid-lineage cells with highly inflammatory but distinct transcriptional signatures in each compartment, and suggests that transcriptomic profiling can provide an understanding of the pathogenesis of CO VID-19 in individual patients.
Journal ArticleDOI
Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients.
Samuele Notarbartolo,Valeria Ranzani,Alessandra Bandera,Alessandra Bandera,Paola Gruarin,Valeria Bevilacqua,Anna Rita Putignano,Andrea Gobbini,Andrea Gobbini,Eugenia Galeota,Cristina Manara,Mauro Bombaci,Elisa Pesce,Elena Zagato,Andrea Favalli,Maria Lucia Sarnicola,Serena Curti,Mariacristina Crosti,Martina Martinovic,Tanya Fabbris,Federico Marini,Lorena Donnici,Mariangela Lorenzo,Marilena Mancino,Riccardo Ungaro,Andrea Lombardi,Davide Mangioni,Antonio Muscatello,Stefano Aliberti,Stefano Aliberti,Francesco Blasi,Tullia Maria De Feo,Daniele Prati,Lara Manganaro,Francesca Granucci,Francesca Granucci,Antonio Lanzavecchia,Raffaele De Francesco,Andrea Gori,Andrea Gori,Renata Grifantini,Sergio Abrignani +41 more
TL;DR: In this article, the authors integrated phenotypic, transcriptional and repertoire analyses on PBMCs from mild and severe COVID-19 patients during and after infection, and compared them to healthy donors (HD).
Journal ArticleDOI
Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective.
Kartikay Prasad,Fatima Khatoon,Summya Rashid,Nemat Ali,Abdullah F. Alasmari,Mohammad Z. Ahmed,Ali S. Alqahtani,Mohammed S. Alqahtani,Vijay Kumar +8 more
TL;DR: Analysis of transcriptomic profile of human alveolar adenocarcinoma cells infected with SARS-CoV-2 and network centric analysis suggests that moderating the innate immune response is a valuable approach to target COVID-19.
Journal ArticleDOI
RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation.
Yaoxing Wu,Ling Ma,Sihui Cai,Zhen Zhuang,Zhiyao Zhao,Zhiyao Zhao,Shouheng Jin,Weihong Xie,Lingli Zhou,Lei Zhang,Jincun Zhao,Jun Cui +11 more
TL;DR: Wang et al. as discussed by the authors demonstrated that SARS-CoV-2 nucleocapsid (N) protein, the major structural protein of the virion, promotes the virus-triggered activation of NF-κB signaling.
Journal ArticleDOI
SARS-CoV-2 evades immune detection in alveolar macrophages
Louise Dalskov,Michelle Møhlenberg,Jacob Thyrsted,Julia Blay-Cadanet,Ebbe Toftgaard Poulsen,Birgitte Holst Folkersen,Søren Helbo Skaarup,David Olagnier,Line S. Reinert,Jan J. Enghild,Hans Jürgen Hoffmann,Hans Jürgen Hoffmann,Christian K. Holm,Rune Hartmann +13 more
TL;DR: It is demonstrated that challenged AMs are incapable of sensing SARS‐CoV‐2 and of producing an IFN response in contrast to other respiratory viruses, like influenza A virus and Sendai virus, which trigger a robustIFN response.
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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