Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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The intersection of COVID-19 and autoimmunity.
Jason S. Knight,Roberto Caricchio,Jean-Laurent Casanova,Alexis J. Combes,Betty Diamond,Sharon E. Fox,David A. Hanauer,Judith A. James,Yogendra Kanthi,Virginia Ladd,Puja Mehta,Aaron M. Ring,Ignacio Sanz,Carlo Selmi,Russell P. Tracy,Paul J. Utz,Catriona A. Wagner,Julia Y. Wang,W. Joseph McCune +18 more
TL;DR: The potential role of auto-immunity in post-acute sequelae of COVID-19 pneumonia was discussed in this paper, highlighting the current understanding, evolving concepts, and unanswered questions provided by this unique opportunity to determine mechanisms by which a viral infection can be exacerbated by, and even trigger, auto-IMM.
Journal ArticleDOI
Mink, SARS-CoV-2, and the Human-Animal Interface
Florence Fenollar,Oleg Mediannikov,Max Maurin,Christian Devaux,Christian Devaux,Philippe Colson,Anthony Levasseur,Pierre-Edouard Fournier,Didier Raoult +8 more
TL;DR: In this article, an outbreak of SARS-CoV-2 in a mink farm was reported in the Netherlands and since then, COVID-19 has reached numerous mink farms in Denmark, Denmark, United States, France, Greece, Italy, Spain, Sweden, Poland, Lithuania, and Canada.
Journal ArticleDOI
The immuno-oncological challenge of COVID-19
Lisa Derosa,Lisa Derosa,Lisa Derosa,Cléa Melenotte,Franck Griscelli,Franck Griscelli,Bertrand Gachot,Bertrand Gachot,Aurélien Marabelle,Aurélien Marabelle,Aurélien Marabelle,Guido Kroemer,Laurence Zitvogel +12 more
TL;DR: Why those with cancer are at higher risk of severe CO VID-19 are discussed, immune responses that confer protective or adverse reactions to this disease are described and which antineoplastic therapies may either increase COVID-19 vulnerability or have a dual therapeutic effect on cancer and COVID the virus.
Journal ArticleDOI
The miRNA: a small but powerful RNA for COVID-19.
Song Zhang,Kuerbannisha Amahong,Xiuna Sun,Xichen Lian,Jin Liu,Huaicheng Sun,Yan Lou,Feng Zhu,Yunqing Qiu +8 more
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SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production.
Keli Chen,Feng Xiao,Dingwen Hu,Weiwei Ge,Mingfu Tian,Wenbiao Wang,Pan Pan,Kailang Wu,Jianguo Wu,Jianguo Wu +9 more
TL;DR: Wang et al. as discussed by the authors showed that the nucleocapsid (N) protein of SARS-CoV-2 plays an important role in the inhibition of interferon beta (IFN-β) production.
References
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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