Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis.
Jarbas da Silva Motta Junior,Anna Flavia Ribeiro dos Santos Miggiolaro,Seigo Nagashima,Caroline Busatta Vaz de Paula,Cristina Pellegrino Baena,Julio Scharfstein,Lucia de Noronha +6 more
TL;DR: In this paper, the authors report histopathology data obtained in post-mortem lung biopsies of COVID-19, showing the increased density of perivascular and septal mast cells (MCs) and IL-4-expressing cells (n = 6).
Journal ArticleDOI
Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs.
Jonathan Lopez,Marine Mommert,William Mouton,William Mouton,Andrés Pizzorno,Karen Brengel-Pesce,Mehdi Mezidi,Marine Villard,Bruno Lina,Jean-Christophe Richard,Jean-Baptiste Fassier,Valérie Cheynet,Blandine Padey,Victoria Duliere,Victoria Duliere,Thomas Julien,Thomas Julien,Stéphane Paul,Paul Bastard,Paul Bastard,Paul Bastard,Alexandre Belot,Alexandre Belot,Antonin Bal,Jean-Laurent Casanova,Manuel Rosa-Calatrava,Manuel Rosa-Calatrava,Florence Morfin,Thierry Walzer,Sophie Trouillet-Assant +29 more
TL;DR: In this article, the expression of ISGF-3-dependent IFN-stimulated genes in mildly symptomatic COVID-19 patients and show its correlation with serum IFNα2 levels, which peak at symptom onset and return to baseline from day 10 onward.
Journal ArticleDOI
COVID-19: immunopathology, pathophysiological mechanisms, and treatment options.
Larissa E. van Eijk,Mathijs Binkhorst,Arno R. Bourgonje,Annette K. Offringa,Douwe J. Mulder,Eelke M. Bos,Nikola Kolundzic,Nikola Kolundzic,Amaal Eman Abdulle,Peter H. J. van der Voort,Marcel G. M. Olde Rikkert,Johannes G. van der Hoeven,Wilfred F. A. den Dunnen,Jan-Luuk Hillebrands,Harry van Goor +14 more
TL;DR: A review of the main pathological changes observed in COVID-19 within the most commonly affected organ systems, with special emphasis on immunopathology, is provided in this paper, which provides valuable information with regard to our understanding of pathophysiology as well as the development of evidence-based treatment regimens.
Posted ContentDOI
Disparate temperature-dependent virus - host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium
Philip V'kovski,Mitra Gultom,Silvio Steiner,Jenna N. Kelly,Julie Russeil,Bastien Mangeat,Elisa Cora,Joern Pezoldt,Melle Holwerda,Annika Kratzel,Laura Laloli,Manon Wider,Jasmine Portmann,Thao Dang-Hien Tran,Nadine Ebert,Hanspeter Stalder,Rune Hartmann,Vincent Gardeux,Vincent Gardeux,Daniel Alpern,Daniel Alpern,Bart Deplancke,Bart Deplancke,Volker Thiel,Ronald Dijkman +24 more
TL;DR: Time-resolved transcriptome analysis highlighted a temperature-dependent and virus-specific induction of the IFN-mediated antiviral response in SARS-CoV-2, and provided crucial insight on pivotal virus - host interaction dynamics.
Journal ArticleDOI
Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy.
TL;DR: This study presents a distinct mechanism of probable virus induced lung damage apart from cytokine storm, and suggests that SARS-CoV-2 infection might lead to acute lung injury in COVID-19 by affecting surfactant proteins and their regulators SPD, SPC, and TTF1 through NSP5 and NSP12.
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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