Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12.
Yun Teng,Fangyi Xu,Xiangcheng Zhang,Xiangcheng Zhang,Jingyao Mu,Mohammed Sayed,Xin Hu,Chao Lei,Mukesh K. Sriwastva,Anup Kumar,Kumaran Sundaram,Lifeng Zhang,Juw Won Park,Shao-Yu Chen,Shuangqin Zhang,Jun Yan,Michael L. Merchant,Xiang Zhang,Craig J. McClain,Craig J. McClain,Jennifer K. Wolfe,Robert S. Adcock,Donghoon Chung,Kenneth E. Palmer,Huang-Ge Zhang,Huang-Ge Zhang +25 more
TL;DR: In this article, exosomesNsp12Nsp13 are taken up by lung macrophages, leading to activation of nuclear factor κB (NF-κB) and the subsequent induction of an array of inflammatory cytokines.
Journal ArticleDOI
Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling
Yaoxing Wu,Ling Ma,Zhen Zhuang,Sihui Cai,Zhiyao Zhao,Lingli Zhou,Jing Zhang,Pei-Hui Wang,Jincun Zhao,Jun Cui +9 more
TL;DR: This work has confirmed that RIG-I is required for IFNB induction by SARS-CoV-2 infection and inhibited type I IFN production, and sought to determine the inhibition of M in both IRF3-mediated and NFκB pathway using IFN-stimulated response element (ISRE) and NF-κB luciferase reporters separately.
Journal ArticleDOI
Age-related mitochondrial dysfunction as a key factor in COVID-19 disease.
TL;DR: It is suggested here that chronic inflammation caused by mitochondrial dysfunction is responsible of the explosive release of inflammatory cytokines causing severe pneumonia, multi-organ failure and finally death in COVID-19 patients.
Journal ArticleDOI
The Relevance of a Physical Active Lifestyle and Physical Fitness on Immune Defense: Mitigating Disease Burden, With Focus on COVID-19 Consequences.
Tayrine Ordonio Filgueira,Angela Castoldi,Lucas Eduardo Rodrigues Santos,Geraldo José de Amorim,Matheus Santos de Sousa Fernandes,Weydyson de Lima do Nascimento Anastácio,Eduardo Zapaterra Campos,Tony Meireles Santos,Fabrício Oliveira Souto +8 more
TL;DR: In this article, the effects of physical activity in physical fitness, immune defense, and its contribution to mitigate the severe inflammatory response mediated by SARS-CoV-2 infection is discussed.
Journal ArticleDOI
COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury.
TL;DR: In this paper, the authors reviewed the vascular pathology of COVID-19 and critically discussed the potential mechanisms of endothelial injury in this disease, and suggested that the indirect mechanism of vascular injury mediated locally by an augmented inflammatory reaction to infected nonendothelial cells, such as the bronchial and alveolar epithelium, and systemically by the excessive immune response to infection.
References
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Journal ArticleDOI
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
Journal ArticleDOI
Fast gapped-read alignment with Bowtie 2
TL;DR: Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
Book
ggplot2: Elegant Graphics for Data Analysis
TL;DR: This book describes ggplot2, a new data visualization package for R that uses the insights from Leland Wilkisons Grammar of Graphics to create a powerful and flexible system for creating data graphics.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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