Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
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Integrative Genomics Analysis Reveals a 21q22.11 Locus Contributing Risk to COVID-19.
Yunlong Ma,Yukuan Huang,Sen Zhao,Yinghao Yao,Yaru Zhang,Jia Qu,Nan Wu,Jianzhong Su,Jianzhong Su +8 more
TL;DR: Wang et al. as mentioned in this paper performed a meta-analysis of two independent genome-wide association summary datasets (N = 680 128), and a novel locus at 21q22.11 was identified to be associated with COVID-19 infection (rs9976829 in IFNAR2-IL10RB, OR = 1.16, 95% CI 1.09-1.23, P = 2.8 × 10-24).
Posted ContentDOI
Genome-wide, bidirectional CRISPR screens identify mucins as critical host factors modulating SARS-CoV-2 infection
Scott B. Biering,Sylvia A Sarnik,Eleanor Wang,James Zengel,Varun Sathyan,Xammy Nguyenla,Erik Van Dis,Carmelle Catamura,Lívia H. Yamashiro,Adam Begeman,Jessica C. Stark,D. Judy Shon,Douglas M. Fox,Andreas S. Puschnik,Carolyn R. Bertozzi,Carolyn R. Bertozzi,Jan E. Carette,Sarah A. Stanley,Eva Harris,Silvana Konermann,Patrick D. Hsu +20 more
TL;DR: In this article, the authors conducted genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of the SARS-CoV-2 entry factors ACE2 and TMPRSS2.
Journal ArticleDOI
Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker for severe pneumonia.
Marta Camici,Paolo Zuppi,Patrizia Lorenzini,Liliana Scarnecchia,Carmela Pinnetti,Stefania Cicalini,Emanuele Nicastri,Nicola Petrosillo,Fabrizio Palmieri,Gianpiero D'Offizi,Luisa Marchioni,Roberta Gagliardini,Roberto Baldelli,Vincenzo Schininà,Elisa Pianura,Federica Di Stefano,Stefano Curcio,Lucia Ciavarella,Giuseppe Ippolito,Enrico Girardi,Francesco Vaia,Andrea Antinori +21 more
TL;DR: In this article, the authors investigated the association between sex hormones and the severity of coronavirus disease 2019 (COVID-19) and found that low levels of testosterone were a marker of clinical severity of COVID19.
Journal ArticleDOI
The Global Impact of COVID-19 on Solid Organ Transplantation: Two Years Into a Pandemic
TL;DR: The global impact of COVID-19 on transplant activity, donor evaluation, and patient outcomes over the past 2 y is summarized, the current strategies aimed at preventing and treating SARS-CoV-2 infection in SOT recipients are discussed, and steps the transplant community could consider as preparation for future pandemics are proposed.
Journal ArticleDOI
Is the Endothelium the Missing Link in the Pathophysiology and Treatment of COVID-19 Complications?
Pedro Castro,Marta Palomo,Ana Belen Moreno-Castaño,Sara Fernández,Sergi Torramade-Moix,Georgina Pascual,Julia Martinez-Sanchez,Edward Richardson,Adrián Téllez,Josep M. Nicolás,Enric Carreras,Paul G. Richardson,Juan J. Badimon,Gines Escolar,Maribel Diaz-Ricart +14 more
TL;DR: In this article, the clinical features of SARS-CoV-2 infection, the central role of the endothelium in COVID-19 and in other pathologies, and the potential of specific therapies aimed at protecting the endothelialium in patients are addressed.
References
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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