Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TLDR
It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.About:
This article is published in Cell.The article was published on 2020-05-28 and is currently open access. It has received 3286 citations till now.read more
Citations
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Journal ArticleDOI
Genetic influences on viral-induced cytokine responses in the lung
TL;DR: How host genetic variation may influence cytokine responses to respiratory viral infections is discussed and, based on the current understanding of the role that cytokines play in viral pathogenesis, how this may influence disease severity.
Journal ArticleDOI
SARS-CoV-2 Switches 'on' MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression.
Swati Goel,Fatemeh Saheb Sharif-Askari,Narjes Saheb Sharif Askari,Bushra Madkhana,Ahmad Munzer Alwaa,Bassam Mahboub,Bassam Mahboub,Adel M Zakeri,Elaref Ratemi,Rifat Hamoudi,Qutayba Hamid,Qutayba Hamid,Rabih Halwani,Rabih Halwani +13 more
TL;DR: A comprehensive analysis of publicly available gene expression data sets of human airway epithelial cells (AECs) infected with SARS-CoV-2 identified dual-specificity phosphatases (DUSP1 and DUSP5) among the lowest induced transcripts within these pathways as discussed by the authors.
Journal ArticleDOI
Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution.
Dustin Griesemer,Dustin Griesemer,Dustin Griesemer,James R. Xue,James R. Xue,Steven K. Reilly,Steven K. Reilly,Jacob C. Ulirsch,Jacob C. Ulirsch,Kalki Kukreja,Joe R. Davis,Masahiro Kanai,Masahiro Kanai,David K. Yang,John C. Butts,Mehmet Hakan Guney,Jeremy Luban,Jeremy Luban,Stephen B. Montgomery,Hilary K. Finucane,Hilary K. Finucane,Carl D. Novina,Carl D. Novina,Ryan Tewhey,Ryan Tewhey,Pardis C. Sabeti,Pardis C. Sabeti,Pardis C. Sabeti +27 more
TL;DR: The massively parallel reporter assay for 3' untranslated region (MPRAu) as mentioned in this paper was developed to sensitively assay 12,173 3'UTR variants and applied to six human cell lines, focusing on genetic variants associated with genomewide association studies (GWAS) and human evolutionary adaptation.
Journal ArticleDOI
Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses.
Arinjay Banerjee,Nader El-Sayes,Patrick Budylowski,Rajesh Abraham Jacob,Daniel Richard,Hassaan Maan,Jennifer A. Aguiar,Wael L. Demian,Kaushal Baid,Michael R. D’Agostino,Jann Catherine Ang,Tetyana Murdza,Benjamin J.-M. Tremblay,Sam Afkhami,Mehran Karimzadeh,Aaron T. Irving,Aaron T. Irving,Lily Yip,Mario A. Ostrowski,Mario A. Ostrowski,Jeremy A. Hirota,Jeremy A. Hirota,Robert A. Kozak,Robert A. Kozak,Terence D. Capellini,Matthew S. Miller,Bo Wang,Samira Mubareka,Samira Mubareka,Allison McGeer,Allison McGeer,Andrew G. McArthur,Andrew C. Doxey,Andrew C. Doxey,Karen L. Mossman +34 more
TL;DR: In this article, the authors demonstrate that SARS-CoV-2 infection induces a type I IFN response in vitro and in moderate cases of COVID-19 severity.
Journal ArticleDOI
Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection.
Bin Yang,Junpeng Fan,Jia Huang,Ensong Guo,Yu Fu,Si Liu,Rourou Xiao,Chen Liu,Funian Lu,Tianyu Qin,Chao He,Zizhuo Wang,Xu Qin,Dianxing Hu,Lixin You,Xi Li,Tian Wang,Peng Wu,Gang Chen,Jianfeng Zhou,Kezhen Li,Chaoyang Sun +21 more
TL;DR: The negative correlation between the RP levels and viral shedding duration was validated in an independent cohort of bulk-RNA-sequencing data from 103 non-critical patients, which may help guide clinical management and resource allocation.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
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