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Laser speckle contrast imaging in biomedical optics

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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.
Abstract
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.

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Citations
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Diffuse Optical Biomarkers Of Breast Cancer

TL;DR: A novel DOS prognostic marker for predicting pathologic complete response to neoadjuvant chemotherapy using z-score normalization and logistic regression was developed and demonstrated and found that tumors that were not hypoxic relative to the surrounding tissue were more likely to achieve complete response, which could enable dynamic feedback for the optimization of chemotherapy.
Proceedings ArticleDOI

Imaging beyond scattering limits utilizing ARF as a guidestar

TL;DR: In this paper, the authors proposed to use acoustic radiation force (ARF) to tag the light that travels through the ultrasound focal spot and generate a stronger signal, which can be used to generate the stiffness image of the medium.
Dissertation

Modelling Blood Flow & Oxygen Transport in the Active Brain

TL;DR: A novel mathematical model of blood flow and oxygen transport in the active brain is developed and used to investigate three aspects of the functional hyperemia response and suggests that a mechanism with effects similar to functional recruitment is required in order to produce model predictions that are consistent with in vivo data.
Proceedings ArticleDOI

Analysis of microvascular perfusion with multi-dimensional complete ensemble empirical mode decomposition with adaptive noise algorithm: Processing of laser speckle contrast images recorded in healthy subjects, at rest and during acetylcholine stimulation

TL;DR: The recent multi-dimensional complete ensemble empirical mode decomposition with adaptive noise (MCEEMDAN) algorithm is applied to LSCI data and the results show that the intrinsic mode functions and residue given by MCEemDAN show different patterns for the two physiological states.
Journal ArticleDOI

Chronic cranial window for photoacoustic imaging: a mini review

TL;DR: In this article, the development of chronic cranial windows for PA imaging is reviewed and its technical details are discussed, including window installation, imaging quality, and longitudinal stability, which are major challenges for long-term in vivo PA imaging.
References
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BookDOI

Dynamic Light Scattering

Robert Pecora
Journal ArticleDOI

Pathobiology of ischaemic stroke: an integrated view

TL;DR: This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain.
Book

Statistical Optics

Journal ArticleDOI

Spreading depression of activity in the cerebral cortex

TL;DR: In this article, an interesting response elicited by electrical stimulation was noticed in the cortex of rabbits, and the distinctive feature of this response was a marked, enduring reduction of the "spontaneous" electrical activity of the cortex.
ReportDOI

Statistical properties of laser sparkle patterns

TL;DR: In this article, the first order statistics of the observed electric-field strength, the observed light intensity, and observed light phase are examined, and the autocorrelation functions of the complex field and intensity processes are investigated, and that of the electric field is found to be proportional to the Fourier transform of the light intensity distribution incident on the scattering surface.
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