Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
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Improvement of estimation parameter for frame-rate analysis of blood flow using laser speckle image sensing
TL;DR: Improved estimation parameters for frame-rate analysis of blood flow in skin tissue and a blood vessel using laser speckle image sensing are proposed for visualizing a blood flow distribution with improving image quality and computation time or with reducing effects of aSpeckle contrast and random noises.
Journal ArticleDOI
Alteration of Blood Flow in a Venular Network by Infusion of Dextran 500: Evaluation with a Laser Speckle Contrast Imaging System
TL;DR: It is confirmed that RBC aggregation could play a dominant role in modulating microvascular perfusion, particularly in the venular networks.
Journal ArticleDOI
Robust quantitative single-exposure laser speckle imaging with true flow speckle contrast in the temporal and spatial domains
TL;DR: The efficacy of the proposed true flow speckle contrast is demonstrated by imaging phantom flow at varying speeds, and the proposed LSCI analysis framework paves the way to estimate the true flow speed in the wide array of laser speckel contrast imaging applications.
Journal ArticleDOI
Noninvasive noncontact speckle contrast diffuse correlation tomography of cerebral blood flow in rats.
Chong Huang,Siavash Mazdeyasna,Li Chen,Elie G. Abu Jawdeh,Henrietta S. Bada,Kathryn E. Saatman,Lei Chen,Guoqiang Yu +7 more
TL;DR: An innovative noncontact speckle contrast diffuse correlation tomography system was downscaled and adapted for noninvasive imaging of CBF distributions in rat brain through intact scalp and skull to provide a non invasive noncontact cerebral imager for basic neuroscience research in small animal models and clinical applications in human neonates.
Evaluating anesthetic protocols for functional blood flow imaging in the rat eye
WooJhon Choi,David A. Boas,Allen C. Clermont,Edward P. Feener,Eric M. Moult,Bernhard Baumann,James G. Fujimoto +6 more
TL;DR: It is observed that different anesthetic protocols produced markedly different blood flows, and the choice of anesthetic protocol should be carefully considered when designing and interpreting functional blood flow studies in the rat eye.
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