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Laser speckle contrast imaging in biomedical optics

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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.
Abstract
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.

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Journal ArticleDOI

Static laser speckle contrast analysis for noninvasive burn diagnosis using a camera-phone imager

TL;DR: It is suggested that relative changes in the static-to-dynamic scattering composition of burns can dominate relative changesIn blood flow for burns of different severity, showing the potential to enable LASCA-based burn diagnosis with a simple imager.
Journal ArticleDOI

Focusing and energy deposition inside random media

TL;DR: Through calculations and simulations, it is discovered that the variation with depth of the maximal energy density and the contrast in optimal focusing are determined by the participation number M(z) of the energy density eigenvalues, while its inverse gives the variance of theEnergy density at z in a single configuration.
Journal ArticleDOI

Architecture of the rat nephron-arterial network: analysis with micro-computed tomography.

TL;DR: An irregular-network tree structure with vascular nodes, where arteriolar activity and local blood pressure interact, is suggested, where juxtamedullary nephrons have longer afferent arterioles and more widespread synchronization is predicted.
Journal ArticleDOI

Real-time monitoring of bacterial growth kinetics in suspensions using laser speckle imaging.

TL;DR: This work shows that laser speckle imaging is a reliable technique that can be used to perform real-time monitoring of bacteria growth kinetic in liquid culture media and shows that bothSpeckle grain size and spatial contrast decrease with bacterial growth.
Journal ArticleDOI

Enriched Environment Elicits Proangiogenic Mechanisms After Focal Cerebral Ischemia

TL;DR: Exposure to EE promotes angiogenesis in the ischemic brain that may in part be mediated by blood-borne factors, and this effect is associated with greater improvement in neurological function and higher peri-infarct vascular density.
References
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BookDOI

Dynamic Light Scattering

Robert Pecora
Journal ArticleDOI

Pathobiology of ischaemic stroke: an integrated view

TL;DR: This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain.
Book

Statistical Optics

Journal ArticleDOI

Spreading depression of activity in the cerebral cortex

TL;DR: In this article, an interesting response elicited by electrical stimulation was noticed in the cortex of rabbits, and the distinctive feature of this response was a marked, enduring reduction of the "spontaneous" electrical activity of the cortex.
ReportDOI

Statistical properties of laser sparkle patterns

TL;DR: In this article, the first order statistics of the observed electric-field strength, the observed light intensity, and observed light phase are examined, and the autocorrelation functions of the complex field and intensity processes are investigated, and that of the electric field is found to be proportional to the Fourier transform of the light intensity distribution incident on the scattering surface.
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