Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
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Journal ArticleDOI
Design and evaluation of a miniature laser speckle imaging device to assess gingival health.
Caitlin Regan,Sean M. White,Bruce Y. Yang,Thair Takesh,Jessica Ho,Cherie Wink,Petra Wilder-Smith,Bernard Choi +7 more
TL;DR: In this paper, a compact laser speckle imaging (LSI) system that can be mounted in custom-made oral molds was used to measure gingival blood flow.
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Measuring neuronal activity with diffuse correlation spectroscopy: a theoretical investigation.
TL;DR: In this paper, the authors modeled the variations in the diffusion correlation spectroscopy signal that are expected to arise from neuronal activation using Monte Carlo simulations, including the impacts of neuronal cell motion, vessel wall dilation, and blood flow changes.
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Experimental characterization of the speckle pattern at the output of a multimode optical fiber.
TL;DR: This work studies experimentally how the speckle pattern depends on the laser pump current and on the image acquisition settings, and finds conditions that allow for recorded images with similar average intensity, but withSpeckle contrast (the standard deviation of the intensity over the average intensity) as low as 0.16.
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Biophotonics for blood analysis
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In vivo monitoring of microneedle-based transdermal drug delivery of insulin
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