Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
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Excellent inter- and intra-observer reproducibility of microvascular tests using laser speckle contrast imaging.
TL;DR: Microvascular tests using LSCI have an excellent intra- and inter-observer reproducibility and CVs for peak determination are better than for baseline or plateau determination for both microv vascular tests, suggesting that when microvascular vasodilations are reported, the data segments measured have to be noted.
Journal ArticleDOI
Comparison of speckleplethysmographic (SPG) and photoplethysmographic (PPG) imaging by Monte Carlo simulations and in vivo measurements.
TL;DR: An eight-layer tissue model is developed to simulate both PPG and SPG signals in a reflectance geometry via Monte Carlo methods and suggests SPG has a much larger SNR than PPG, which may prove beneficial for noncontact, wide-field optical monitoring of cardiovascular health.
Journal ArticleDOI
A novel effective method for the assessment of microvascular function in male patients with coronary artery disease: a pilot study using laser speckle contrast imaging
Juliana Pereira Borges,Gabriella de Oliveira Lopes,V. Verri,Marina Pereira Coelho,Pablo Marino Correa Nascimento,Daniel Arkader Kopiler,Eduardo Tibiriçá +6 more
TL;DR: Laser speckle contrast imaging appears to be an efficient non-invasive technique for evaluating systemic microvascular and endothelial functions, which could be valuable as a peripheral marker of atherothrombotic diseases in men.
Journal ArticleDOI
Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance
Ramesh Chennupati,Angela Wirth,Julie Favre,Rui Li,Remy Bonnavion,Young-June Jin,Astrid Wietelmann,Frank Schweda,Nina Wettschureck,Nina Wettschureck,Daniel Henrion,Stefan Offermanns,Stefan Offermanns +12 more
TL;DR: It is concluded that G12/G13- and Rho-mediated signaling plays a key role in myogenic vasoconstriction and that myogenic tone is required to maintain local and systemic vascular resistance under physiological and pathological condition.
Journal ArticleDOI
Laser speckle contrast imaging is sensitive to advective flux
TL;DR: It is argued that the diffusion with drift equation can be used to support both Lorentzian and Gaussian correlation models that relate observed contrast to the movement of the scattering particles and that a weighted linear combination of these two models is likely the most appropriate model for relating speckle contrast to particle motion.
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