Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
Citations
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Journal ArticleDOI
Laser Speckle Contrast Imaging for the Objective Assessment of Blood Perfusion in Keloids Treated With Dual-Wavelength Laser Therapy.
TL;DR: In this paper, the authors evaluated the value of laser speckle contrast imaging (LSCI) as an objective method for the assessment of dual-wavelength laser therapy for keloids.
Journal ArticleDOI
Quantification of the effectivity of laser therapy shortly following brain injury via dual-wavelength laser imaging
TL;DR: The hypothesis that a high dose of laser irradiation as a first aid can attenuate the injury and save the brain from further worse outcome is supported.
Journal ArticleDOI
Quantitative analysis of hidden particles diffusing behind a scattering layer using speckle correlation
TL;DR: It is shown that a correlation analysis can be applied to quantitative imaging of an ensemble of dynamic fluorescent beads diffusing on a 2D surface and the diffusion constant and number of fluorescent particles in the sample without requiring any phase retrieval procedure.
Posted ContentDOI
Dexmedetomidine — commonly used in resting-state and neurovascular coupling studies — is prone to inducing seizures in rats but not in wild type mice
TL;DR: The susceptibility to dexmedetomidine-induced seizures is species dependent and it is shown that these seizures are associated with spatially extensive high-amplitude cerebral blood flow and blood oxygenation responses, prone to be misinterpreted as normal responses in functional imaging studies that do not use neurophysiological recordings.
Proceedings ArticleDOI
The cerebral blood flow response dependency on stimulus pulse width is affected by stimulus current amplitude - a study of activation flow coupling
TL;DR: LSCI is used to study the spatiotemporal CBF response to hindpaw somatosensory stimulation of different pulse widths and current amplitudes in a rodent experiment and showed that the change of pulse width significantly affected the CBF peak value at a lower current level.
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