Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
Citations
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Journal ArticleDOI
Decreased cerebral blood flow and hemodynamic parameters during acute hyperglycemia in mice model observed by dual‐wavelength speckle imaging
TL;DR: The findings indicate that acute hyperglycemia modified brain hemodynamic response and induced significant changes in blood flow and metabolism.
Journal ArticleDOI
Influence of wavefront types on movement artefacts in handheld laser speckle contrast perfusion imaging
TL;DR: It is shown that the scrambled waves made by often-used engineered diffusers lead to significantly larger movement artefacts than planar or spherical waves.
Journal ArticleDOI
Deep Learning-Based Image Analysis for the Quantification of Tumor-Induced Angiogenesis in the 3D In Vivo Tumor Model—Establishment and Addition to Laser Speckle Contrast Imaging (LSCI)
Paulina Mena Kuri,Eric Pion,Lina Mahl,Philipp Kainz,Siegfried Schwarz,Christoph Brochhausen,Thiha Aung,Silke Haerteis +7 more
TL;DR: The CAM assay application appears to be a useful method for the quantification of angiogenesis in the CAM model and gluconate could be a potential treatment of angiosarcomas.
Journal ArticleDOI
Exercise and Repeated Testing Improves Accuracy of Laser Doppler Assessment of Microvascular Function Following Shortened (1-minute) Blood Flow Occlusion.
Brian D. Tran,Abraham Chiu,Charlene Tran,Danica Rose Rogacion,Nicole Tfaye,Goutham Ganesan,Pietro Galassetti +6 more
TL;DR: To determine whether stability/accuracy of post‐occlusive LDF following shortened, one‐minute blood flow occlusion, increases in the post‐exercise state or by averaging multiple measurements, averages multiple measurements are averaged.
Book ChapterDOI
Laser Speckle Imaging of Cerebral Blood Flow
TL;DR: The physical underpinnings of laser speckle imaging are introduced as well as the most important technical and practical aspects of its implementation.
References
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