Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
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Quantitative determination of dynamical properties using coherent spatial frequency domain imaging
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TL;DR: In this article, the authors combine LSI with spatial frequency domain imaging, a technique where samples are illuminated with sinusoidal intensity patterns of light that control the characteristic path lengths of photons in the sample.
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Lateral laser speckle contrast analysis combined with line beam scanning illumination to improve the sampling depth of blood flow imaging
TL;DR: Both the phantom and animal experimental results suggest that localized illumination and lateral speckle contrast analysis can significantly enhance the deep blood flow signal to improve the sampling depth of laser specksle contrast imaging compared with the traditional full-field illumination laser speckles contrast analysis method.
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Optical imaging of resting-state functional connectivity in a novel arterial stiffness model
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Decoherence of fiber supercontinuum light source for speckle-free imaging.
TL;DR: The evolutionary process of supercontinuum decoherence in extra-large mode area step-index multimode fiber is analyzed to provide high-quality broadband light source for speckle-free imaging and it is found that spectral bandwidth, number of spatial transverse modes, anddecoherence among different modes all greatly contribute to speckles reduction.
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