Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
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Journal Article
Laser speckle contrast imaging: multifractal analysis of data recorded in healthy subjects
TL;DR: In this paper, a multifractal analysis of LSCI data recorded in the forearm of healthy subjects, based on the method from Halseyet et al., one of the popular methods using the box-counting technique.
Journal ArticleDOI
Determination of the effect of source intensity profile on speckle contrast using coherent spatial frequency domain imaging.
TL;DR: LSI measurements are found that spatial variations in the laser source profile can impact measured flow rates, and cSFDI is found to accurately predict speckle contrast for all beam shapes to within 5% root mean square error.
Patent
Methods for laser speckle contrast imaging of blood perfusion
TL;DR: In this article, a method for imaging blood flow through target tissue is disclosed, where a light beam is directed at a blood-perfused target tissue, reflecting the directed light beam off of static target tissue and flowing cells, capturing a plurality of digital images of interference patterns of the reflected light in successive frames, and determining a compiled light intensity for the at least one pixel for an aggregate motion contrast.
Journal ArticleDOI
Segmentation of Renal Perfusion Signals From Laser Speckle Imaging Into Clusters With Phase Synchronized Dynamics
TL;DR: In three out of six animals imaged after bolus infusion of Nω-nitro-l-arginine methyl ester (NAM), the renal surfaces are segmented into clusters with high phase coherence, and a strong myogenic signal could not be detected in surface perfusion during control or NAM.
Journal ArticleDOI
Fiber-based laser speckle imaging for the detection of pulsatile flow.
Caitlin Regan,Bruce Y. Yang,Kent C. Mayzel,Julio C. Ramirez-San-Juan,Julio C. Ramirez-San-Juan,Petra Wilder-Smith,Bernard Choi +6 more
TL;DR: A fiber‐based laser speckle imaging system is designed and characterized to study pulsatile blood flow in the tooth to study pulp status and its role in endodontics.
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