Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
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Journal ArticleDOI
Evaluating anesthetic protocols for functional blood flow imaging in the rat eye
Eric M. Moult,WooJhon Choi,David A. Boas,Bernhard Baumann,Allen C. Clermont,Edward P. Feener,James G. Fujimoto +6 more
TL;DR: In this article, the suitability of five different anesthetic protocols (isoflurane, xylazine, pentobarbital, ketamine, and ketamine-xylazine-vecuronium) for functional blood flow imaging in the rat eye was evaluated.
Journal ArticleDOI
Combined laser speckle imaging and fluorescent intravital microscopy for monitoring acute vascular permeability reaction
Vyacheslav Kalchenko,Igor Meglinski,Igor Meglinski,Igor Meglinski,Anton Sdobnov,Yuri Kuznetsov,Alon Harmelin +6 more
TL;DR: The obtained results suggest that a combined use of LSI and FIM is highly effective for monitoring the cutaneous vascular permeability reaction, with great potential for assessment of allergic reactions of skin in response to interactions with chemical substances.
Patent
Noncontact Three-dimensional Diffuse Optical Imaging of Deep Tissue Blood Flow Distribution
Guoqiang Yu,Yu Lin,Chong Huang +2 more
TL;DR: In this paper, a three-dimensional reflectance diffuse optical imaging of deep tissue blood flow distribution is proposed to remove the need for probe-tissue contact, thereby allowing for such technology to be applied to sensitive, vulnerable, damaged, or reconstructive tissue.
Journal ArticleDOI
Target delivery of drug carriers in mice kidney glomeruli via renal artery. Balance between efficiency and safety.
Ekaterina S. Prikhozhdenko,Olga I Gusliakova,Oleg A. Kulikov,Oksana A. Mayorova,Natalia A. Shushunova,Arkady S. Abdurashitov,Daniil N. Bratashov,Nikolay A. Pyataev,Valery V. Tuchin,Dmitry A. Gorin,Gleb B. Sukhorukov,Olga A. Sindeeva,Olga A. Sindeeva +12 more
TL;DR: Efficacy of fluorescent dye localization in the target kidney after intra-arterial administration is 9 times higher than in the opposite kidney and after intravenous injection, and a high level of fluorescent signal persists for 48 h indicating that fluorescent cargo accumulation in tissues.
Journal ArticleDOI
Ergodic and non-ergodic regimes in temporal laser speckle imaging
TL;DR: It is demonstrated that temporal speckle statistics assessed within a finite time window might differ from the statistics of the Speckle ensemble, and the positive relation in the non-ergodic regime is an artifact of temporal statistics which is further quantify and describe the transition between two regimes.
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