Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
Citations
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Journal ArticleDOI
Laser speckle contrast imaging of cerebral blood flow in freely moving animals
TL;DR: This work designs a miniature laser speckle imager that weighs ∼20 g and is 3.1-cm high for full-field high-resolution imaging of cerebral blood flow (CBF) in freely moving animals and achieves high spatiotemporal resolution laser Speckle contrast imaging of CBF in freelyMoving animals in real time.
Journal ArticleDOI
Relevance of Laser Doppler and Laser Speckle Techniques for Assessing Vascular Function: State of the Art and Future Trends
TL;DR: How-using engineering methodologies-LDF, LDI, and LSCI can meet the challenging clinician needs in assessing vascular function is described, with a special focus on the state of the art and future trends.
Journal ArticleDOI
Spatial Frequency Domain Imaging of Intrinsic Optical Property Contrast in a Mouse Model of Alzheimer’s Disease
Alexander J. Lin,Maya A. Koike,Kim N. Green,Jae Gwan Kim,Amaan Mazhar,Tyler B. Rice,Frank M. LaFerla,Bruce J. Tromberg +7 more
TL;DR: The results show that SFDI is capable of revealing quantitative functional contrast in an AD model and may be a useful method for studying dynamic alterations in AD neural tissue composition and physiology.
Journal ArticleDOI
State of the Art of X-ray Speckle-Based Phase-Contrast and Dark-Field Imaging
TL;DR: An overview of the state of the art of the X-ray speckle-based technique is provided, its basic principles and different experimental implementations as well as the the latest advances and applications are illustrated.
Book
Quantitative Biomedical Optics: Theory, Methods, and Applications
Irving J. Bigio,Sergio Fantini +1 more
TL;DR: In this article, a broad range of areas in biomedical optics, from light interactions at the single-photon and single-biomolecule levels, to the diffusion regime of light propagation in tissue, are covered.
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