Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
Citations
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References
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Journal ArticleDOI
Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging
TL;DR: The results suggests that approximately 5 ms is an optimal exposure time for imaging of stimulus-induced changes in cerebral blood flow in rodents.
Journal Article
Noncontact, two-dimensional measurement of retinal microcirculation using laser speckle phenomenon.
TL;DR: A new apparatus for noncontact, two-dimensional measurement of retinal microcirculation using the laser speckle phenomenon is reported and it is demonstrated that this apparatus can document known or expected changes in retinal blood flow.
Journal ArticleDOI
Investigating non-Gaussian scattering processes by using nth-order intensity correlation functions
TL;DR: In this paper, the authors proposed to extend the traditional analysis by introducing intensity correlation functions g(n) of higher order, which allow both to detect non-Gaussian scattering processes and to extract information not available in g(2) alone.
Journal ArticleDOI
Non-contact, two-dimensional measurement of tissue circulation in choroid and optic nerve head using laser speckle phenomenon.
TL;DR: The results suggest that by using the present apparatus, the blood velocity in the choroid or ONH under various conditions can be studied non-invasively in the living eye.
Journal ArticleDOI
Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex.
Anthony J. Strong,Peter J B Anderson,Helena R. Watts,David Virley,Andrew R. Lloyd,Elaine A. Irving,Toshiaki Nagafuji,Mitsuyoshi Ninomiya,Hajime Nakamura,Andrew K. Dunn,Rudolf Graf +10 more
TL;DR: In this model of occlusive stroke, reductions in perfusion linked to peri-infarct depolarization events contribute to secondary deterioration in penumbral areas and are suggested to play a central rather than a subsidiary role in cerebral infarction in the gyrencephalic brain.
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