Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
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Journal ArticleDOI
Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance.
TL;DR: A modified form of laser speckle imaging referred to as affixed transmission Speckle analysis (ATSA) that uses a single coherent light source to probe two physiological signals related to pulsatile vascular expansion and flow is introduced.
Journal ArticleDOI
Interferometric near-infrared spectroscopy directly quantifies optical field dynamics in turbid media.
TL;DR: Interferometric near-infrared spectroscopy is demonstrated for measuring the time-of-flight (TOF) resolved field and intensity autocorrelations in turbid media and finds that the Siegert relationship breaks down for short TOFs due to static paths whose optical field does not decorrelate over experimental time scales.
Journal ArticleDOI
Correcting the detrimental effects of nonuniform intensity distribution on fiber-transmitting laser speckle imaging of blood flow
TL;DR: A normalized laser speckle spatial contrast analysis (nLSSCA) is presented to correct the detrimental effects of nonuniform intensity distribution on the spatial statistics and could be a potential tool for fiber-transmitting/endoscopic laser Speckle imaging.
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The Role of Laser Speckle Imaging in Port-Wine Stain Research: Recent Advances and Opportunities
Bernard Choi,Wenbin Tan,Wangcun Jia,Sean M. White,Wesley J. Moy,Bruce Y. Yang,Jiang Zhu,Zhongping Chen,Kristen M. Kelly,J. Stuart Nelson +9 more
TL;DR: In this article, a combination of photodynamic therapy (PDT) and pulsed-dye laser (PDL) irradiation achieves a synergistic effect that reduces the required radiant exposures of the individual phototherapies to achieve persistent vascular shutdown.
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Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress
Howard H. Carter,Peijun Gong,Rodney W. Kirk,Rodney W. Kirk,Shaghayegh Es'haghian,Ceri L. Atkinson,David D. Sampson,Daniel J. Green,Daniel J. Green,Robert A. McLaughlin +9 more
TL;DR: This is the first in vivo within-subject assessment of acute changes in the cutaneous microvasculature in response to heating in humans and highlights the use of OCT as an exciting new imaging approach for skin physiology and clinical research.
References
More filters
Journal ArticleDOI
Pathobiology of ischaemic stroke: an integrated view
TL;DR: This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain.
Journal ArticleDOI
Spreading depression of activity in the cerebral cortex
TL;DR: In this article, an interesting response elicited by electrical stimulation was noticed in the cortex of rabbits, and the distinctive feature of this response was a marked, enduring reduction of the "spontaneous" electrical activity of the cortex.
ReportDOI
Statistical properties of laser sparkle patterns
TL;DR: In this article, the first order statistics of the observed electric-field strength, the observed light intensity, and observed light phase are examined, and the autocorrelation functions of the complex field and intensity processes are investigated, and that of the electric field is found to be proportional to the Fourier transform of the light intensity distribution incident on the scattering surface.
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