Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
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Visualizing odor representation in the brain: a review of imaging techniques for the mapping of sensory activity in the olfactory
TL;DR: Functional imaging techniques developed in the last 30 years are reviewed, summarising the major results obtained and describing promising technical developments in optical imaging and future directions in the study of olfactory spatiotemporal coding.
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Multi-scale laser speckle correlation imaging with the low-frequency acquisition
TL;DR: In this article , a new multi-scale laser speckle correlation imaging technique was proposed to measure compound hemodynamics in several fields of view and the relative image sharpness metric of the β map was improved by 2.25 times of the τ map calculated from the same model.
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Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system
Byungchan Kim,Sharvari Zilpelwar,Edbert J. Sie,Francesco Marsili,Bernhard B. Zimmermann,David A. Boas,Xiao-Tong Cheng +6 more
TL;DR: In this article , a fiber-based speckle contrast optical spectroscopy (SCOS) system and corresponding data analysis pipeline were developed to measure cerebral blood flow variations and showed that SCOS outperforms traditional DCS by more than an order of magnitude in SNR with comparable financial cost.
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A stochastic differential equation based algorithm to simulate laser speckles for deep tissue blood flow imaging applications
Murali k,Hari M. Varma +1 more
TL;DR: In this article, an intensity speckle simulation algorithm based on stochastic differential equations is presented for both surface and deep tissue blood flow with potential applications in diffuse correlation spectroscopy.
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Microcirculatory dysfunction associates with neurovascular uncoupling in peri-ischemic brain regions after ischemic stroke
Christian Staehr,John T. Giblin,Eugenio Gutiérrez-Jiménez,H. Guldbrandsen,Jianbo Tang,Shaun L. Sandow,David A. Boas,Vladimir Macko +7 more
TL;DR: Arterial occlusion led to constriction of pericytes in the peri-ischemic cortex associated with long-lasting microcirculatory failure, which may, at least in part, underlie impaired neurovascular coupling inperi-ISChemic brain regions after stroke and reperfusion.
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